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Apr 08 2018 23 mins   9
This week on PA Study Sesh, we’ll learn about Rheumatology.
A note about ANA, RF, ESR, CRP
ANA: Antinuclear antibodies
Shows antibodies against self
Can be positive in healthy people
Also induced by certain drugs & cancers
CRP: C-reactive protein
Produced in the early stages of inflammatory process.
ESR: erythrocyte sedimentation rate “sed rate”
Rate at which rbcs settle
RF: Rheumatoid Factor
Autoantibody to a fragment of IgG
In Summary: These are all NONSPECIFIC and only clue you in to the presence of inflammation and auto-immune disease. They do not help you definitively distinguish one disease from another and therefore (in my opinion) are not worth memorizing their absence/presence in each disease for PANCE/PANRE purposes.

* Chronic, widespread muscle pain
* Middle aged women
* Associated fatigue, fibro fog
* Diffuse pain in 11/18 trigger points >3 months
* Clinical diagnosis
* Tx: exercise (swimming), OTC pain medication, TCA

Reactive Arthritis (Reiter Syndrome)

* Autoimmune response to an infection elsewhere
* Young males most common
* Arthritis, conjunctivitis/uveitis, urethritis
* Keratoderma blenorrhagicum (hyperkeratotic lesions on palms/soles)
* s/p chlamydia #1, may also follow gonorrhea or GI infections
* Labs: Often HLA B-27 + (young males like ankylosing spondylitis)
* Can’t pee, can’t see, can’t climb a (bamboo) tree, can’t sleep with me

* Abx if infection not treated


* Uric acid
* Most patients are under excretors, which explains why associated with food consumption
* Purine-rich foods, TZD, ACE/ARBs, ASA, Pyrazinamide, Ethambutol (TAPE)
* Men most common
* 1st MTP joint = podagra
* Red, swollen, tender joint
* Arthrocentesis=gold standard

* Negatively birefringent, needle shaped urate crystals

* Tophi: colletion of solid uric acid (ears, eyelids, fingers)
* X-ray

* Rate bite erosions (recurrent)

* Tx:

* Acute: NSAIDS (indomethacin), but avoid ASA

* 2nd line= colchicine

* Chronic:

* Colchicine (can be used in both!)
* Probenecid (uricosuric drug)= increase excretion
* Allopurinol (Xanthine Oxidase Inhibitor)- decreases uric acid production, so not used in acute disease.


* Calcium pyrophosphate
* Large joints. Knee #1
* Red, swollen, tender joint
* Arthrocentesis:

* Postitively birefringent prism shaped (rhomboid)

* Tx: NSAIDS, steroid injection

* Colchicine also used acute & chronic.

* Prophylaxis if more than 3 attacks per year

Juvenile RA

* AKA juvenile idiopathic arthritis
* Prior to age 16, typically resolves by puberty
* 3 types

* Oligoarticular (50%)

* Less than 5 joints involved in the first 6 months (typically large joints)
* Swollen, tender, warm, without erythema
* May have concomitant anterior uveitis

* Refer to ophthomology

* + ANA
* Symptomatic treatment (NSAIDS)

* Polyarticular (30%)

* Most similar to adult RA

* If in a teenager, consider early RA presentation

* >5 joints involved during 1st 6 months (usually symmetric)
* Eye involvement less common, but possible
* + ANA +/- RF

* Systemic (20%) Still’s Disease

* Intermittent,