Nettlesome is an adjective that means irritable or difficult.
A plant called the nettle has jagged leaves covered with stinging hairs. And this irritable plant naturally gave birth to our word of the day which means irritable. The old meaning of nettlesome was ‘to beat or sting someone with nettles,’ but more recently the word is used in a figurative sense, such as: Don’t get me wrong, I appreciate the fact that my nephew has a curious mind. But his endless questions can be nettlesome after a while.