Medscape InDiscussion: Lung Cancer

Drs Jacob Sands and Hossein Borghaei discuss small cell lung cancer, including breakthroughs and challenges in immunotherapy.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999031. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

First-Line Atezolizumab Plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer https://pubmed.ncbi.nlm.nih.gov/30280641/

Durvalumab Plus Platinum-Etoposide Versus Platinum-Etoposide in First-Line Treatment of Extensive-Stage Small-Cell Lung Cancer (CASPIAN): A Randomised, Controlled, Open-Label, Phase 3 Trial https://pubmed.ncbi.nlm.nih.gov/31590988/

Paclitaxel-Carboplatin Alone or With Bevacizumab for Non-Small-Cell Lung Cancer https://pubmed.ncbi.nlm.nih.gov/17167137/

Nivolumab Monotherapy and Nivolumab Plus Ipilimumab in Recurrent Small Cell Lung Cancer: Results From the CheckMate 032 Randomized Cohort https://pubmed.ncbi.nlm.nih.gov/31629915/

Pembrolizumab for the Treatment of Non-Small-Cell Lung Cancer https://pubmed.ncbi.nlm.nih.gov/25891174/

Pembrolizumab in Patients With Advanced Non-Small-Cell Lung Cancer (KEYNOTE-001): 3-Year Results From an Open-Label, Phase 1 Study https://pubmed.ncbi.nlm.nih.gov/30876831/

Topotecan Versus Cyclophosphamide, Doxorubicin, and Vincristine for the Treatment of Recurrent Small-Cell Lung Cancer https://pubmed.ncbi.nlm.nih.gov/10080612/

Phase III Trial Comparing Supportive Care Alone With Supportive Care With Oral Topotecan in Patients With Relapsed Small-Cell Lung Cancer https://pubmed.ncbi.nlm.nih.gov/17135646/

Lurbinectedin as Second-Line Treatment for Patients With Small-Cell Lung Cancer: A Single-Arm, Open-Label, Phase 2 Basket Trial https://pubmed.ncbi.nlm.nih.gov/32224306/

Topotecan Weekly Versus Conventional 5-Day Schedule in Patients With Platinum-Resistant Ovarian Cancer: a randomized multicenter phase II trial of the North-Eastern German Society of Gynecological Oncology Ovarian Cancer Study Group https://pubmed.ncbi.nlm.nih.gov/21115872/

Beyond Overall Survival: Considering Quality of Life in the Treatment of Early Non-Small Cell Lung Cancer https://www.medscape.com/viewarticle/999479

Tarlatamab for Patients With Previously Treated Small-Cell Lung Cancer https://pubmed.ncbi.nlm.nih.gov/37861218/