JACI: In Practice Editor David Khan describes the November issue, the theme of which is Nonsteroidal Anti-inflammatory Drug-Exacerbated Respiratory Disease (NSAID-ERD). Theme topics covered include the burden, natural history, clinical characteristics, inflammatory heterogeneity, and biologic and non-biologic treatment of NSAID-ERD. Dr. Khan then presents the Highlights of the Original Articles in the issue, which are on the topics of Asthma, Dermatitis, Drug Allergy, Eosinophilic Disorders, Food Allergy, and Rhinitis and Sinusitis.