This Week in Virology

Oct 18 2020 94 mins 15.5k

TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.



























































































































































































































































































TWiV 438: Drs. TWiV go to Washington
Apr 23 2017 102 mins  
On the eve of the March for Science, the TWiV team gathers at ASM Headquarters in Washington, DC with guests Stefano and Susie to talk about the state of science communication. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guests: Stefano Bertuzzi and Susan Sharp Become a patron of TWiV! Links for this episode Journal of Microbiology & Biology Education sci comm issue ASM Cultures Stefano Bertuzzi and the scientists' big picture (Washington Post) March for Science The March for Science (NY Times) I have always marched for science (virology blog) A scientist who studies marches on the March (Atlantic) What exactly are people marching for (Atlantic) Explaining science won't fix information illiteracy Letters read on TWiV 438 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Alan - Steve Ballmer’s government data project (NYTimes article) Rich - Alexander Hamilton by Ron Chernow Dickson - Shanghai vertical farming Vincent - Right-to-try sham and NASA mediaStefano - Why Religion is Natural and Science is Not and The Path Between the Seas Susan - Rick and Morty Listener Pick Johnye - A capella CRISPR/Cas9 Intro music is by Ronald Jenkees. Send your virology questions and comments to [email protected]















TWiV 426: I'm Axl, and I'll be your cervid today
Jan 29 2017 109 mins  
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The sages of TWiV explain how chronic wasting disease of cervids could be caused by spontaneous misfolding of prion protein, and the role of the membrane protein Axl in Zika virus entry into cells. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM 2017 election is now open - VOTE HERE ASM Election questions: Which positions are we voting for? What is the ASM Board of Directors? Organization Chart What is the Council on Microbial Sciences? Organization Chart FAQs Scientists March on Washington Spontaneous generation of unique cervid strain (mSphere) Zika virus entry into human glial cells via Axl (Cell Rep) Article collections: PNAS, Cell, Nature, Virology Letters read on TWiV 426 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv. Weekly Science Picks Alan - Deerland by Al Cambronne Dickson - Antarctica's Colorful Underwater World Kathy - You can’t unring a bell #1 and #2 Rich - Extra letters added to life's genetic code (source) and The Doomsday Clock (wiki) Vincent - Trump Science Advisors, National Parks Won't Be Silenced Listener Pick Stefan - The Vital Question by Nick Lane Kevin - Scientists March on Washington? Dennis - Fractal Tree of Life Send your virology questions and comments to [email protected]




TWiV 422: Watching the icosahedron drop
Jan 01 2017 116 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVestigators wrap up 2016 with a discussion of the year's ten compelling virology stories. Become a patron of TWiV! Should auld infections be forgotAnd never T-cells primed?Will cross-reacting antigensProtect the host next time? Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens Ten virology stories from 2016 Zika virus (first covered in 2015, TWiV 368) Ebolavirus Eukaryotic genes in Wolbachia phage (TWiV 412) Harold "400" Varmus (TWiV 400) and many other guests Vaccines Mutualism Mosquitoes and viruses Vector victorious (TWiV 401) Animal models of virus infections Virus evolution Current Zika virus infections (ECDC) Early Zika virus infections in Hawaii (PLoS NTD) Zika virus vaccine for whom? (NYTimes) Final results for Ebola virus vaccine (Lancet) Photo from Mohammad Letters read on TWiV 422 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. Weekly Science Picks Alan - North America's Lost Medieval City Dickson - New Views of Pillars of Creation Kathy - Reilly Top Ten Rich - Everyday Einstein Vincent - Naples' Sleeping Volcano Might Be Waking Up Listener Pick John - RadioLab: The Times They Are a-Changin' Send your virology questions and comments to [email protected]



TWiV 420: Orthogonal vectors
Dec 18 2016 115 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV gurus describe how to use an orthogonal translation system to produce infectious but replication-incompetent influenza vaccines. Become a patron of TWiV! Links for this episode Register for ASV 2017 Local Zika virus transmission in Texas Texaszika.org Local dengue virus transmission in Texas (EID) No more Zika virus transmission in Florida (FL DOH) Dengue virus antibodies enhance Zika virus infection (Clin Trans Imm) Infectious, replication incompetent influenza virus vaccine (Science) Pyrrolysl-tRNA synthetase (Biochem Biophys Acta) History of nonsense suppression (Stan Maloy) Suppression of poliovirus amber mutant (Cell) Remembering mumps (PLoS Path) Letters read on TWiV 420 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. Weekly Science Picks Alan - Superbugs game Dickson - Dinosaur tail trapped in amber Rich - Earth's Rotation is Slowing (original article)Kathy - Lithium Ion batteries (one and two) Vincent - Truth and Lies in the Age of Trump (virology blog) and self driving Uber car Listener Pick Steve - New York City Street Tree Map Justin - Transmissible vaccines? Send your virology questions and comments to [email protected]


TWiV 418: Of mice and MERS
Dec 04 2016 104 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVsters describe a new animal model for MERS coronavirus-induced acute respiratory distress syndrome, produced by CRISPR/Cas9 editing of the mouse gene encoding an ortholog of the virus receptor. Become a patron of TWiV! Links for this episode New mouse model for MERS (Nat Micro) RNA-guided genome engineering (Science) Photo by Finny Letters read on TWiV 418 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 27:50 This show is sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. This Holiday season give someone a Drobo to keep all their files and memories safe forever. TWiV listeners can save 20% or more off of their purchase of a Drobo 5D, Drobo 5Dt, Drobo 5N, or any 8-drive or 12-drive system at www.drobostore.com by December 31, 2016 using discount code MICROBE20. Register for ASV 2017 at Madison, Wisconsin Weekly Science Picks Alan - Human population through time Dickson - Every Orbit Cassini Has Taken Rich - OK GO: Walk Her WalkKathy - Medieval Bestiary Online Vincent - Can You Out-Science an Eighth Grader? and Stitchen Pox Listener Pick Hannah - Bioart and Bacteria Send your virology questions and comments to [email protected]


TWiV 417: O is the loneliest letter
Nov 27 2016 110 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The Fellowship of the Virus trace the early history of HIV in North America, based on genome sequences obtained from late 1970s archival sera, which also reveal that Gaetan Dugas was not Patient Zero. Become a patron of TWiV! Links for this episode WHO: Zika virus is no longer a PHEIC World AIDS Day Early HIV/AIDS history in North America (Nature) Dugas was not AIDS patient zero (virology blog) Image credit Letters read on TWiV 417 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm Register for the 2017 ASM Grant Writing Online course. Weekly Science Picks Alan - VP8SGI Dickson - New leaf-shaped spider discovered Rich - Dance of Earth and Venus About the SunKathy - Cultivar Series, Mutatoes, Uli Westphal site Vincent - Kung Fu Mantis vs Jumping Spider Send your virology questions and comments to [email protected]

TWiV 416: Scattered seeds dormant
Nov 20 2016 126 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The multi-dimensional TWiV-brane bring you the entries in the haiku/limerick contest, and explain how a giant virus infects a host within another host (it has to do with predators!). Become a patron of TWiV! Links for this episode Predators allow virus infection of endosymbiont (PNAS) Image credit Letters read on TWiV 416 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 1:34:40 Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 5:05 Register for the 2017 ASM Grant Writing Online course. Weekly Science Picks Alan - Cubes in Space Dickson - The Architecture of Eden by H. Pearlman and A. Whalley Rich - Studying the building blocks of life in stereo (original paper)Kathy - Ancient bottom wipes yield evidence of diseases (original paper) Vincent - Iguana vs snakes Send your virology questions and comments to [email protected]

TWiV 415: Ebola pipettors and the philosopher's clone
Nov 13 2016 110 mins  
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guests: Jeremy Luban, Aaron Lin, and Ted Diehl Jeremy, Aaron, and Ted join the TWiV team to discuss their work on identifying a single amino acid change in the Ebola virus glycoprotein from the West African outbreak that increases infectivity in human cells. Become a patron of TWiV! Links for this episode Ebola virus glycoprotein with increased infectivity (Cell) Effect in cells of Ebola virus mutations from West African outbreak (Cell) Ebola virus in semen for over 500 days (Clin Inf Dis) Puzzling origin of 2014 Ebola virus outbreak (J Virol) Mutant Ebola virus may have caused explosive outbreak (Goats and Soda) Virus Genomics and Evolution website This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 1:05:40 Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 1:35 Register for the 2017 ASM Grant Writing Online course. Weekly Science Picks Jeremy – Real time tracking of Ebola virus evolutionTed - The Brain Scoop Aaron - Kate Rubins sequencing DNA on ISS (video) Alan – A Sand County Almanac by Aldo Leopold Rich – Vendee GlobeKathy – Axios Vincent – Vendors from above by Loes Heerinck Send your virology questions and comments to [email protected]



TWiV 413: Partnerships not parachutes
Oct 30 2016 71 mins  
Hosts: Vincent Racaniello, Alan Dove, and Paul Duprex Guests: Ralph Baric, Felix Drexler, Marion Koopmans, and Stacey Schultz-Cherry From the EIDA2Z conference at Boston University, Vincent, Alan and Paul meet up with Ralph Baric, Felix Drexler, Marion Koopmans, Stacey Schultz-Cherry to talk about discovering, understanding, protecting, and collaborating on emerging infectious diseases. Become a patron of TWiV! Links for this episode EIDA2Z meeting MERS-CoV infection of Alpaca (EID) Origins of HAV in small mammals (PNAS) WHO recommendations on influenza vaccine composition Collaborative Cross mice Video of this episode at YouTube This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm Send your virology questions and comments to [email protected]

TWiV 412: WO, open the borders and rig the infection
Oct 23 2016 121 mins  
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Mark Fuccio The TWiVome reveal the first eukaryotic genes found in a bacteriophage of Wolbachia, and how DNA tumor virus oncogenes antagonize sensing of cytoplasmic DNA by the cell. Become a patron of TWiV! Links for this episode Zika virus in vaginal secretions (EID) Zika virus in semen (EID) Eukaryotic genes in a bacteriophage (Nat Commun) Seth Bordenstein on TWiV 332 DNA tumor virus oncogenes antagonize cGAS-STING (Science) Letters read on TWiV 412 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Weekly Science Picks Mark - EFN Enterprise Futures Network and Mission Log Podcast Alan - 2016 Wildlife Comedy Photography Rich - ZuTA, portable robotic printerKathy - How LEGO help blind people see Vincent - Airplane photos of Mike Kelley Listener Pick Hannah - Frozen Flow Glass (Instagram) Send your virology questions and comments to [email protected]

TWiV 411: Chicken runs
Oct 16 2016 95 mins  
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The TWiVeroos examine a reverse spillover of Newcastle disease virus vaccines into wild birds, and identification of a protein cell receptor for murine noroviruses. Become a patron of TWiV! Links for this episode MicrobeTV Store Florida DOH Daily Zika Update Zika virus in new Miami neighborhood (CNN, NYTimes) NDV vaccine virus in wild birds (PLoS One) Protein cell receptor for murine norovirus (Science, PNAS) Poliovirus receptor analysis (J Virol) Letters read on TWiV 411 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Weekly Science Picks Alan - Braincraft Rich - Now is the Greatest Time to Be AliveKathy - CRISPR/Cas9 by A Capella Science Vincent - Microbes After Hours: The Necromicrobiome Listener Pick Jolene - Chalk Talk Science by Dennis Mangan Send your virology questions and comments to [email protected]

TWiV 410: Hurricane Zika
Oct 09 2016 120 mins  
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guests: Sharon Isern and Scott Michael Sharon and Scott join the TWiV team to talk about their work on dengue antibody-dependent enhancement of Zika virus infection, and identifying the virus in mosquitoes from Miami. Become a patron of TWiV! Links for this episode Live at Florida Gulf Coast University (TWiV #111) Florida DOH Daily Zika Update Regional Zika update, Americas (PAHO, WHO) NJ Zika Bill Dengue virus antibodies enhance Zika virus infection (bioRxiv) First detection of Zika virus in Brazilian A. aegyptii (Mem Inst Oswaldo Cruz) 2017 ASM Scientific Writing and Publishing Online Course Letters read on TWiV 410 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Weekly Science Picks Sharon - Zika virus comics and cartoons and Florida weekly arbovirus reportsScott - Real-time tracking of Zika virus evolution Alan - Evolution of antibiotic resistance on a mega plate Rich - WindytvKathy - Zika virus map and timeline Vincent - Ohsumi Nobel advanced information and HR 5325 funding breakdown Send your virology questions and comments to [email protected]

TWiV 409: A Nef is enough
Oct 02 2016 124 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Jeremy Luban Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles. Become a patron of TWiV! Links for this episode No recovery in PACE trial (virology blog) The real PACE data (virology blog) Contagious Thinking Florida DOH daily Zika update Congress does not fail on Zika (NPR) Nef history (Luban lab) Nef excludes SERINC from virions (Nature) SERINC counters Nef (Nature) ASM Grant Writing Online Course Letters read on TWiV 409 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 28:50 This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Weekly Science Picks Alan - Migration in MotionDickson - Beautiful Chemistry Rich - XKCD Timeline of Earth Temperature Kathy - Vaccine Heroes from Vaccine Education CenterJeremy - CIDRAP posters and Demon in the Freezer Vincent - People Peas and Pathogens Listener Picks Matlock - Science isn't broken Send your virology questions and comments to [email protected]





TWiV 406: Pow, right in the enteroids!
Sep 11 2016 97 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team discussed eye infections caused by Zika virus, failure of Culex mosquitoes to transmit the virus, and replication of norovirus in stem cell derived enteroids. Become a patron of TWiV! Links for this episode Florida DOH daily Zika update Congress fails again on Zika (NY Times) Culex pipiens does not support Zika virus replication (EID) Zika virus in the eye (Cell Rep) Norovirus replication in enteroids (Science) Norovirus replication in B cells (TWiV 312) Baylor press release Norovirus replication in B cells confirmed (Antiviral Res) Letters read on TWiV 406 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Weekly Science Picks Alan - Infective PerspectiveDickson - The Living RiverRich - Freddy Mercury around the Sun Kathy - A Day in PompeiiVincent - Spraying Pesticides Listener Picks Ricardo - Why the metric system mattersEric - The Giving Plague by David Brin Send your virology questions and comments to [email protected]

TWiV 405: All the world's a phage
Sep 04 2016 116 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler The TWiXers discuss a study on vertical transmission of Zika virus by Aedes mosquitoes, and uncovering Earth's virome by mining existing metagenomic sequence data. Become a patron of TWiV! Links for this episode Roger Tsien, 64 (UC San Diego Health) CDC running out of Zika money (NYTimes) Zika virus in Miami mosquitoes (NYTimes) No Zika virus in Rio Olympics (NYTimes) Vertical transmission of Zika virus in Aedes aegypti (AJTMH) Uncovering Earth's virome (Nature) Image credit (Global water volume) Letters read on TWiV 405 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 58:55 This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Weekly Science Picks Alan - The VizziesDickson - NASA Spinoff Kathy - Maps.meVincent - Zika: The Emerging Epidemic by Donald McNeil Listener Picks Tarwin - Darwin's Radio by Greg Bear (paper or Kindle)Bodham - The start of scientific publishing, 1665 Send your virology questions and comments to [email protected]

TWiV 404: Not found
Aug 28 2016 126 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit From the twiVivants, follow up on FluMist and Zoster vaccines, Zika virus update, and isolation of a multicomponent animal virus from mosquitoes. Become a patron of TWiV! Links for this episode FluMist problem (FDA) DA Henderson obituary (NY Times) DA Henderson, smallpox eradicator (TWiV Special) Efficacy of VZV vaccine (Ther Adv Vaccines) Zika virus burden, Puerto Rico (JAMA) Zika virus in Miami Beach (STAT) Congenital brain anomalies and Zika virus (Radiology) Congenital Zika syndrome with arthrogryposis (BMJ) Multicomponent animal virus from mosquitoes (Cell Host Microbe) Breaking rules of infection (NPR) Image credit Letters read on TWiV 404 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Weekly Science Picks Alan - Sally Le PageDickson - Comfortably Numb by Jamie Dupuis Rich - Learned HelplessnessVincent - Virus by Marilyn Roossinck Listener Picks OneTime - The Stranglers - Old CodgerSteve - A Poem About Pronunciation Send your virology questions and comments to [email protected]


TWiV 403: It's not easy being vaccine
Aug 21 2016 96 mins  
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, a new adjuvanted subunit zoster vaccine. Become a patron of TWiV! Links for this episode Tribunal orders release of PACE trial data (Valerie Eliot Smith) Our request for PACE trial data (virology blog) GM mosquito release on ballot (NPR) Florida Keys Mosquito Control District on TWiV #111 Cold chain and virus free plant based polio vaccine (Plant Biotechnol J) Disappointing flu vaccine effectiveness (CBC) ACIP votes down use of LAIV (CDC) LAIV as effective as inactivated flu vaccine (Ann Int Med) Flumist does work (NPR) Declining effectiveness of zoster vaccine (J Inf Dis) Efficacy of adjuvanted subunit zoster vaccine (NEJM) Risk of zoster from vaccine (J Inf Dis) Image credit: ViralZone Letters read on TWiV 403 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Weekly Science Picks Alan - To Scale: The Solar SystemRich - Route 66 Goes SolarVincent - Race for a Zika Vaccine by Siddhartha Mukherjee Listener Picks Bohdan - Penn and Teller on VaccinationsBill - Connections, Episode 1 Send your virology questions and comments to [email protected]

TWiV 402: The plight of the bumblebee
Aug 14 2016 117 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Polio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV. Become a patron of TWiV! Links for this episode Marian Horzinek, 80 (ProMedMail) Polio in Nigeria (Atlantic, Stat, ProMedMail) Zika virus spreads in Miami (NYTimes) More Zika virus vaccines (Science) Back to work on Zika, Congress ! (Asbury Park Press) Lack of funding will stymie Zika vaccines (Wash Examiner) FDA OK on genetically modified mosquitoes (FDA) CMV attracts aphid vectors (TWiV #70) CMV attracts pollinating bumblebees (PLoS Path) Earth dwarfed by solar flare (jpg) Letters read on TWiV 402 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Weekly Science Picks Alan - Solar storm that launched US space weather scienceRich - Data storage on DNA Dickson - Perseid meteor show liveVincent - In the Company of Microbes by Elio Schaechter Listener Picks Neva - I Contain Multitudes by Ed YongAmanda - American Gut Send your virology questions and comments to [email protected]

TWiV 401: Vector victorious
Aug 07 2016 118 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Zika virus spreads in the USA, a Zika virus DNA vaccine goes into phase I trials, and how mosquito bites enhance virus replication and disease, from the friendly TWiFolk Vincent, Dickson, Alan, and Kathy. Become a patron of TWiV! Links for this episode Beverly Griffin, 86 (1 2 3) Zika virus in the US (CDC) Zika virus spreading in Miami (CDC) Zika virus in Florida (NY Times) NIH begins phase I trial of Zika virus DNA vaccine (NIAID) Mosquito salive enhances West Nile replication in mice (J Virol) Mosquito bites enhance virus infection (Immunity) Photo of A. aegyptii and mouse ears from Marieke Pingen Letters read on TWiV 401 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Weekly Science Picks Alan - The DoubleclicksKathy - WHO ZIKV app and ZIKV Giant Microbe Dickson - Photographer Rosamond PurcellVincent - Spillover: Zika, Ebola, and Beyond Listener Picks Ricardo - Portugal Four Days on Renewable EnergyFatma - DeNovo: Predicting virus-host protein interactionsStephen - How mosquitoes use six needles to suck your blood Send your virology questions and comments to [email protected]



TWiV 399: Zika la femme
Jul 24 2016 103 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit The latest Zika virus news from the ConTWiVstadors, including a case of female to male transmission, risk of infection at the 2016 summer Olympics, a DNA vaccine, antibody-dependent enhancement by dengue antibodies, and sites of replication in the placenta. Links for this episode Zika virus disease in the US (CDC) Female to male Zika virus transmission (CDC) Zika virus in female genital tract (Lancet) Zika virus transmission in Utah (CDC and NYTimes) Olympic Zika virus risk (CDC) 15 companies on Zika virus vaccines (WSJ) Zika virus DNA vaccine in mice (Nature) Zika virus disease in Colombia (NEJM) Dengue virus antibody dependent enhancement of Zika virus (PNAS) Zika virus antibodies enhance dengue virus disease (Science) Zika virus in human placenta and developing brain (bioRxiv) Zika virus targets different human placenta cells (Cell Host Microbe) Letters read on TWiV 399 This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Become a patron of TWiV. Weekly Science Picks Alan - CDC postmortem on Ebolavirus outbreakRich - Refutations to anti-vaccine memes (Twitter, Facebook) Dickson - History of urbanizationVincent - How to cut subject from background in Photoshop Listener Picks Marion - Skeptics Guide to the Universe podcastJennie - Leatherback turtles in Costa Rica Send your virology questions and comments to [email protected]


















TWiV 383: A zillion Zika papers and a Brazilian
Apr 03 2016 124 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove and Kathy Spindler Guest: Esper Kallas Esper and the Merry TWiXters analyze the latest data on Zika virus and microcephaly in Brazil, and discuss publications on a mouse model for disease, infection of a fetus, mosquito vector competence, and the cryo-EM structure of the virus particle. Links for this episode Zika virus in the Americas (Science) Co-circulation of dengue, Zika, chik in Brazil (Medicine) Murine model for Zika virus infection (Am J Trop Med Hyg) Zika virus susceptibility of A. aegypti and A. albopictus (PLoS NTD) Infectious Zika virus from saliva (EuroSurveill) Zika virus spread through saliva? (Braz Oral Res) Five Zika virus reviews (one, two, three, four, five) Zika virus and microcephaly, Brazil (MMWR) Zika virus in urine (EuroSurveill) Zika virus infection of fetus (NEJM) Real-time sharing of Zika virus data (JAMA) Image credit: Richard Kuhn Letters read on TWiV 383 This episode is sponsored by ASM Agar Art Contest and ASV 2016 Weekly Science Picks Esper - The Chaos by Gérard Nolst Trenité and HIV pathogenesis courseAlan - Science KombatDickson - Four steps to wiping out a mosquitoVincent - Public lacks information on Zika virusKathy - Zika virus cryo-EM structure video Listener Picks Justin - Culture-independent discovery of Archaeal virusMelinda - Zika virus open research portal and Your body battles series Send your virology questions and comments to [email protected]














TWiV 370: Ten out of 15
Jan 03 2016 109 mins  
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler The TWiVomics review ten captivating virology stories from 2015. Ten virology stories from 2015 Recoding to make vaccines and study viral functions: TWiV 351: The dengue codeTWiV 362: Gotta catch ’em all and new paper Defining the virome: TWiV 365: Blood, feuds, and a foodborne disease, TWiV 362: Gotta catch ’em all, TWiV 356: Got viruses?, TWiV 355: Baby’s first virome, TWiV 342: Public epitope #1, TWiV 323: A skid loader full of viromes Ebola outbreak wanes, vaccines tested, persistence noted: TWiV 361: Zombie viruses on the loose, TWiV 349: One ring to vaccinate them all, TWiV 341: Ebolavirus experiences, TWiV 336: Brought to you by the letters H, N, P, and Eye, TWiV 335: Ebola lite Spillovers and scares: TWiV 347: Rose rosette and squirrel roulette, TWiV 351: The dengue code, TWiV 364: It’s not SARS 2.0, TWiV 365: Blood, feuds, and a foodborne disease The “Gain of Function” debate continues: TWiV 321: aTrip and a pause, TWiV 351: The dengue code, TWiV 354: The cat in the HAART, TWiV 363: Eat flu and dyad, and the NSABB’s new draft report Detailed mechanisms of pathogenesis: TWiV 336: Brought to you by the letters H, N, P, and eye, and TWiV 345: How a vaccine got the nod - plus numerous episodes (324, 328, 329, 330, 339, 343, 349, 353, 369) where we talked about basic research that undergirds these clinically important discoveries. Dengue vaccines: Trial TWiV 319: Breaking breakbone. Dengvaxia was licensed in December in Mexico, Philippines, and Brazil (12/28); paper we didn’t have time to cover about broadly neutralizing Abs from viremic patients and another paper from same group with X-ray crystal structure of Ab + gpE. Why do some RNA viruses undergo antigenic variation and others do not? TWiV 340: No shift, measles TWiV 346: A double helical career TWiV 345: How a vaccine got the nod Letters read on TWiV 370 This episode is sponsored by ASM Microbe and ASM Biodefense Weekly Science Picks Alan - Scientifics onlineVincent - Giant squid in Tokyo HarborKathy - A Year of Sky Listener Picks Daniel - Paper LifeStephen - How to deal with science denialistsVenkat - Kabisa Send your virology questions and comments to [email protected]


















TWiV 354: The cat in the HAART
Sep 13 2015 120 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The esteemed doctors of TWiV review a new giant virus recovered from the Siberian permafrost, why influenza virus gain of function experiments are valuable, and feline immunodeficiency virus. Links for this episode Non-viral proteins in vaccinia virus particles (Arch Virol) 8:15 Thing a week (Jonathan Coulton, downloads) 23:20 Immortal Life pornographic? Not! (HuffPost) 25:25 Mollivirus sibericum (PNAS) 27:00 Don't worry about Frankenvirus (WashPost) 27:10 We need flu GOF research (article, Wisc State J, Science) 40:35 Isolation of FIV (Science) 50:20 FIV at Cornell Vet 1:06:25 FIV latency (Retrovirol) 1:08:00 FIV-receptor interactions (Curr Op Virol) 1:08:45 Clin aspects FIV infection (Viruses) FIV antivirals (Viruses) 1:10:05 How to treat FIV 1:10:45 Bud's FIV therapy 1;10;50 FIV vectors (CSH Prot) 1:13:50 Lion FIV (Proc Biol Sci) FIV in cat species (J Virol) 1;01;45 ACIP HVP vaccine recommendations (MMWR) 1:28:45 HPV and cancer (CDC) 1:33:45 Cervical cancer screening (pdf, CDC) Letters read on TWiV 354 7:45, 1:17:10 This episode is sponsored by ASMGAP Timestamps by Jennifer. Thanks! Weekly Science Picks 1:40:40 Alan - Experience CuriosityRich - Primrose SchoolKathy - Egg drop solutionsDickson - Dragonflies by Pieter van DokkumVincent - NASA guide to air-filtering houseplants Listener Pick of the Week Amir - Publons (Nature article) Send your virology questions and comments to [email protected]





































TWiV 321: aTRIP and a pause
Jan 25 2015 100 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Guest: Paul Duprex Paul joins the TWiV team to discuss the current moratorium on viral research to alter transmission, range and resistance, infectivity and immunity, and pathogenesis. Links for this episode Wain-Hobson objects (one, two, three, four) Influenza H7N1 transmission experiments (J Virol) Epistemological perspective on aTRIP experiments (mBio) Limited scientific value and risk (mBio) Reply to limited scientific value (mBio) Risks and benefits of aTRIP experiments (mBio) Apocalypse as rhetorical device in aTRIP debate (mBio) Moratorium on aTRIP experiments Moratorium on aTRIP research (mBio) Risks of influenza virus transmission experiments (mBio) Reply to risks of influenza virus transmission experiments (mBio) Vagueness of moratorium on aTRIP experiments (mBio) Role of aTRIP experiments in vaccine recommendation (mBio) Use of aTRIP data for surveillance and preparedness (mBio) aTRIP towards lexiconic precision (mBio) October 2014 NSABB meeting on aTRIP NAS aTRIP meeting (YouTube) MERS-CoV aTRIP experiments exempted (ScienceInsider) aTRIP: time for a debate (Nat Rev Micro) Effect of aTRIP moratorium on trainee plans (mBio) Make the moratorium permanent (Sci Am) Image credirt: John Morris Letters read on TWiV 321 Weekly Science Picks Alan - In a Sunburned Country by Bill BrysonPaul - Saving the lives of our dogs (blog post)Kathy - New all-female Lego setDickson - Female storm-chaserVincent - Despommier Photo Art Listener Pick of the Week Jacob - Exaggeration in news and press releases (BMJ)Peter - Quartet game (photos: one, two, three, four, five) Send your virology questions and comments (email or mp3 file) to [email protected]










TWiV 312: She sells B cells
Nov 23 2014 93 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC. Links for this episode Ebola virus appropriations (White House) ASM Ebola FAQ Quarantine due to Ebola virus in semen (NPR) Enteric bacteria promote norovirus infection of B cells (Science) Norovirus emerges (Zimmer) Stephanie Karst on TWiV 134 Image credit Letters read on TWiV 312 Weekly Science Picks Alan - How Ebola airlifts workKathy - Fred Murphy's Foundations of VirologyRich - Pendulum waveDickson - Young DipteristsVincent - Microbes After Hours: Ebola and TWiV iPhone 6 case Listener Pick of the Week Alane - Health MapTodd - Formaldehyde in vaccines Send your virology questions and comments (email or mp3 file) to [email protected]




TWiV 309: Ebola email
Nov 02 2014 118 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVocytes answer questions about Ebola virus, including mode of transmission, quarantine, incubation period, immunity, and much more. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC. Links for this episode Guidelines for monitoring potentially infected persons (CDC) ASTMH meeting rejects attendees from Ebola countries (ScienceInsider) Defense Threat Reduction Agency call for Ebola virus proposals NSF calls for Ebola virus proposals Review of Ebola virus human-human transmission (CDC) How Firestone controlled Ebola virus (MMWR) Could Reston virus be a vaccine for Ebola virus? (virology blog) Letters read on TWiV 309 Weekly Science Picks Alan - CDC Influenza activity weekly mapsKathy - Going Deep with David ReesRich - Virology Special Issue: Giant VirusesDickson - Nikon Small World WinnersVincent - TWiM #90 and Republicans are not scientists Listener Pick of the Week Paul - Tricks and Tools of Great ScientistsYegor - Hardcore HistoryAmanda - Vaccine ingredients; Anti-vaxers damage; Minds of anti-vaxers Send your virology questions and comments (email or mp3 file) to [email protected]


TWiV 307: Ebola aetiology
Oct 19 2014 97 mins  
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Guest: Tara C. Smith Tara Smith joins the TWiEBOVsters to discuss the Ebola virus outbreak in west Africa, spread of the disease to and within the US, transmission of the virus, and much more. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC. Links for this episode Science communications fellow at ASM Nation turns to science (New Yorker) CDC employees in West Africa (CDC) UN botched Ebola response (AP) Ebola czar (CNN) Ebola vaccine and budget cuts (HuffPo) Collins' ridiculous meme (NOT junk) How to quarantine against Ebola (Mukherjee) Ebola fear in Heartland (Tara Smith) Massive mutations in Ebola virus (PunditFact) Ebola airport screening (CDC) What is contact tracing? (video) (CDC) Inside MSF Ebola unit (YouTube) Ebola tech bulletin (DuPont) HAI controversies Letters read on TWiV 307 Weekly Science Picks Alan - Fall foliage mapKathy - Interviews with Peter Piot (one, two) and autobiographyVincent - The Ebola connection Listener Pick of the Week Brooke - N.B. Designs on EtsyVictor - SMBC Send your virology questions and comments (email or mp3 file) to [email protected]

TWiV 306: This Week in Ebolavirus
Oct 12 2014 107 mins  
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler The Grand Masters of the TWiV discuss Ebola virus transmission, air travel from West Africa, Ebola virus infectivity on surfaces, the Dallas Ebola virus patient, and Ebola virus in dogs. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC. Links for this episode Science communications fellow at ASM CDC Ebola virus fact sheet (pdf) CDC Ebola virus infographic (pdf) No Reston virus replication in arthropods (Am J Trop Med Hyg) Inoculation of plants and animals with Ebola virus (Emerg Inf Dis) Arthropod studies during Ebola virus outbreak (J Inf Dis) Medbox: Ebola toolbox Facts about bushmeat and Ebola (pdf, CDC) Should US ban incoming flights from West Africa? Survey: should flights from Ebola countries be banned? (NBC News) Ebolavirus content at virology blog and TWiV Volunteer to help with the Ebola virus crisis Ebola and Anthropology webinar Asymptomatic Ebola virus infection (Lancet) Persistence of Ebola virus during 1995 outbreak (J Inf Dis) Assessment of Ebola virus transmission risk (J Inf Dis) Ebola virus transmission risk factors (Emerg Inf Dis) UV inactivation of Ebola virus (J Virol) Ebola virus persistence in darkness (Arch Virol) UV sensitivity of Ebola virus (Arch Virol) Treatment of Ebola virus infection with brincidofovir (virology blog) Ebola virus in domestic animals (Dev Biol) Ebola virus in dogs (Emerg Inf Dis) Ebola screening at US airports (CDC) Letters read on TWiV 306 Weekly Science Picks Alan - The Sixth Extinction by Elizabeth KolbertKathy - Seeing the InvisibleVincent - 2014 Scientific American Science in Action Award winner Listener Pick of the Week Mauricio - Investigating a mystery diseaseHeather - Diversity Journal ClubJohnye - Flu Attack! Send your virology questions and comments (email or mp3 file) to [email protected]

TWiV 305: Rhymes with shinola
Oct 05 2014 92 mins  
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC. Links for this episode Science communications fellow at ASM Can we get AIDS from mosquito bites? (J La State Med Soc) Why mosquitoes cannot transmit AIDS Isolation of Bundibugyo ebolavirus in Uganda (PLoS Path) Ebola virus disease outbreak, Nigeria (MMWR) Nigeria contains Ebola virus outbreak (NY Times) First Ebola virus case in US (NY Times) Ebola virus disease: USA ex Liberia (ProMedMail) First imported Ebola virus case in US (CDC) Assessing risk of spread of Ebola virus (PLoS Currents) How contagious is Ebola virus? (NPR) Estimating reproductive index of Ebola virus (PLoS Currents) Polio-like illness, EV-D68 suspected (ProMedMail) Polio-like illness, North America (ProMedMail) Four deaths associated with EV-D68 (NY Times) Image credit: Pigott et al eLife Letters read on TWiV 305 Video of this episode - view at YouTube Weekly Science Picks Alan - Under the knife, episode 1Kathy - UCSC Ebola genome portalVincent - Annual Review of Virology, volume 1 Listener Pick of the Week Alan - H5N1Peter - Vomiting LarryDara - I just can't wait for my vaccine! Send your virology questions and comments (email or mp3 file) to [email protected]

TWiV 304: Given X, solve for EBOV
Sep 28 2014 97 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Guest: Jeff Shaman The TWiV team consults an epidemiologist to forecast the future scope of the Ebola virus epidemic in West Africa. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC. Links for this episode Science communications fellow at ASM Estimating future cases in Ebola virus epidemic (MMWR) Columbia prediction of Ebola outbreak The Ebola emergency (NEJM) Q&As on Ebola virus transmission (CDC) Ebola virus transmission to monkeys (Lancet) Aerosol infection of monkeys with Ebola virus (Int J Exp Path) Ebola virus replication in pigs (J Inf Dis) Pathology of aerosol Ebola virus infection in rhesus macaques (Vet Path) Murine model of Ebolavirus infection (Viruses) Ebola virus transmission from pigs to non-human primates (Sci Rep) Transmission risks in BSL4 laboratory (Sci Rep) Why Ebola virus is unlikely to go airborne (Vox) Letters read on TWiV 304 Weekly Science Picks Alan - Fabre's Book of InsectsKathy - Origami microscope for 50 centsDickson - Landsat 8Vincent - Some advice from Jeff Bezos Listener Pick of the Week Justin - Brazil releases 'good' mosquitoes to fight dengue fever Send your virology questions and comments (email or mp3 file) to [email protected]


TWiV 303: Borna this way
Sep 21 2014 93 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler The TWiV team discusses transmission of Ebola virus, and inhibition of Borna disease virus replication by viral DNA in the ground squirrel genome. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC. Links for this episode 2014 Ebola virus outbreak at Healthmap Ebola virus transmission from bodily fluids and fomites (JID) Value of gain of function experiments (mBio) Rich Condit in the Washington Post on Ebola virus NPR on Ebola virus transmission What we are not afraid to say about Ebola virus (virology blog) Inhibition of Borna disease virus by an endogenous element (PNAS) Bornavirus at ViralZone Photo: Thirteen-lined ground squirrel (image credit) Letters read on TWiV 303 Weekly Science Picks Alan - PhotogrammarKathy - Refrigerate your tomatoes?Dickson - Robot swarmVincent - The Beginner's guide to winning the Nobel Prize by Peter Doherty Listener Pick of the Week Dee - Publish scientific research faster on TWiSTBasel - Lego microscope (vote for it) Send your virology questions and comments (email or mp3 file) to [email protected]

TWiV 302: The sky is falling
Sep 14 2014 113 mins  
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVers discuss the growing Ebola virus outbreak in West Africa, and an epidemic of respiratory disease in the US caused by enterovirus D68. Links for this episode Cancer patient saved by measles virus Ebola virus genome sequences (Science) Robert Garry on Ebola outbreak Aerosol transmission WHO Ebola outbreak summary CDC Ebola outbreak page Ebola outbreak epi curve CED Ebola outbreak info graphic Ebola response roadmap (CDC) Ebola outbreak discussion at ICAAC Human trial of Ebola virus vaccine (CNN) Chimpanzee adenovirus vectored Ebola virus vaccine (Nat Med) How US Ebola patients were cured (Sci Amer) Ebola outbreak could affect 20,000 (NY Times) Ebola infection control resources NLM free access to Ebola papers Science Ebola papers open access Gates donates money for Ebola outbreak (Wash Post) Smuggled bushmeat? (Newsweek) What we are not afraid to say about Ebola (NY Times) Enterovirus D68 outbreak (MMWR) Mark Pallansch on EV-D68 (NPR) Enterovirus D68 (CDC) EV-D68 isolation 1962 (Am J Ep) Outbreak of enterovirus 68 (virology blog) Letters read on TWiV 302 Weekly Science Picks Alan - Index to creationist claimsRich - Wild KrattsKathy - Worn awayDickson - Iceland volcano eruptionVincent - Immune Quest Listener Pick of the Week Kay - Landes Bioscience open access books Send your virology questions and comments (email or mp3 file) to [email protected]





TWiV 297: Ebola! Don't panic
Aug 10 2014 114 mins  
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The TWiVites present an all-ebolavirus episode, tackling virology, epidemiology, and approaches to prevention and cure that are in the pipeline. Links for this episode Risks and benefits of gain-of-function experiments (mBio) Scientists for Science US Policy for oversight of DURC (pdf) US framework for guiding H5N1 transmission expts (pdf) Extra oversight for H7N9 experiments (Science) TWiV 283: No Reston for the weary Is it Ebolavirus or Ebola virus? (virology blog) Ebola virus disease update (WHO) Ebola virus disease FAQ (WHO) Ebola hemorrhagic fever (CDC) Ebola virus disease: ecology meets economy (PLoS NTD) 2014 Ebola virus outbreak (J Gen Virol) 2014 Ebola virus outbreak (MMWR) If Ebola virus came to the US (Vox) Zaire ebolavirus in West Africa (interview with Tom Solomon) Why Ebola patients were brought to US (Wash Post) Experimental treatment and vaccines for Ebola (CDC) Aerosol transmission of Reston virus (Sci Rep) Ebola - A growing threat? (NEJM) On the cusp of Ebola vaccine (Know) Ebolavirus vaccines and antivirals (virology blog) Immune responses to Ebolavirus infection (Exp Rev Clin Imm) Antibody therapy for Ebola (Hum Vacc Immunother) Plant derived monoclonals protect macaques from Ebolavirus (PNAS) Anti-ebolavirus monoclonal cocktail (Sci Trans Med) ZMapp info sheet (pdf) ZMapp PR (pdf) High tech treatment for Ebola (ArsTechnica) ZMapp protects macaques (Sci Rep) Letters read on TWiV 297 Weekly Science Picks Alan - Historical perspective on Ebola (Tara C Smith)Rich - Tell the negative committee to shut up (Fanuel Muindi)Kathy - Art of Night (Vimeo)Vincent - Is Ebola virus going to kill me? (John Skylar) Listener Pick of the Week Peter - Dr. Michael Saag interview by Dr. Virginia CampbellDavid - PI Predictor (app, article, publication) Send your virology questions and comments (email or mp3 file) to [email protected]
































































































TWiV 213: Not bad for a hobby
Dec 30 2012 122 mins  
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler In their final episode of the year, the TWiV team reviews twelve cool virology stories from 2012. Twelve virology stories from 2012: H5N1 (TWiV 190, 182, 177, 173, 168) Polymorphisms that control susceptibility (TWiV 175, 180) New virus receptors (TWiV 166, 210) XMRV: Last nail in the coffin (TWiV special) Polio eradication troubles in Pakistan (NY Times one, two, three; virology blog) Biomedical research crisis (TWiV 208, 184, 189, 194) Polydnaviruses in parasitoid wasps (TWiV 179) Carolyn Coyne’s placental barrier story (TWiV 193) Touring NEIDL (TWiV 200) Epidemiology (TWiV 169, 178) A good year for virus hunting (173, 183, 195, 196, 198, 199, 204) Pox accordion (TWiV 198) Links for this episode: US plans for H5N1 research (ScienceInsider) FDA recommends against Ampligen Rituximab and CFS (PLoS One) No evidence for XMRV in prostate cancer (PLoS One) Retraction of XMRV prostate cancer paper (Retraction Watch) Gender bias among science faculty (PNAS) NEIDL risk assessment Virology 101 at TWiV Letters read on TWiV 213 Weekly Science Picks Rich - Our Mr. Sun (IMDB entry) (wiki)Alan - PubReader from NCBI announcement and instructionsKathy - Popular Mechanics 110 picks for the next 110 yearsVincent - 366 days: Nature's 10 Listener Pick of the Week Matt - The flu vaccine controversy Send your virology questions and comments (email or mp3 file) to [email protected]



























TWiV 191: When two rights make a wrong
Jul 15 2012 98 mins  
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Nissin Moussatche Nissin joins the TWiV crew to discuss an outbreak of lethal disease among Cambodian children, and recombination among attenuated herpesvirus vaccines leading to pathogenic viruses. Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app. Links for this episode: Outbreak in Cambodia (CNN) Pathogen mix in Cambodian illness (ProMedMail) Undiagnosed illness in Cambodia (WHO) Enterovirus 71 (virology blog) Recombination among attenuated vaccines (Science) An outbreak of irony (Ed Yong) Infectious laryngotracheitis Gallid herpesvirus 1 (Wikipedia) Iltovirus (ViralZone) TWiV on Facebook Letters read on TWiV 191 Weekly Science Picks Alan - H5N1 genetic changes inventoryRich - Mythbusters: Diet Coke and Mentos (YouTube channel)Nissin - The Pox and the Covenant by Tony Williams, and Tired of War by Tereza BatistaVincent - FAQ: The 'snake bite' portion of your thesis defense Listener Pick of the Week Gopal - All's not fair in science and publishingLuis - The Origin of AIDS by Jacques Pepin (Nature review)Sven - Visualizing information flow in science Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
























































































































































































































5 • 5 Ratings

audiofan Aug 21 2020
Very current and informative news and discussions from the world of virology. A nice roundtable discussion where the hosts also correct themselves based on user feedback

efuller Jul 24 2020
Very interesting discussions of viruses






kintiser Jun 23 2020
A wonderfully hosted discussion that deals with the latest in Virus research. This show is hosted by experts in the field and attempts to give a clear unbiased window into the world of Virology in a way that is accessible to anyone who would take the time to listen.

peppigue May 07 2020
Up to date info and discussion about all new research, data and biological/medical news on covid19 and SARS-CoV-2 (and other viruses of course). Nice people who use clear and not unnecessarily complicated language. Useful for anyone who wants to stay up to date, but if you don't have some knowledge in the field from before you will hear some stuff you don't understand.

interstition Apr 12 2020
This, and the other TWIx podcasts, go deep into the science and terminology. So if you can handle that, or want to learn how to, then you won't find anything better!