Featuring articles on PCI before transcatheter aortic-valve implantation, treatments in patients with type 2 diabetes, in leprosy, in refractory adult ALL, and in ATTR cardiomyopathy; a review article on drug reaction with eosinophilia and systemic symptoms; a case report of a boy with recurrent fever; and Perspectives on an autopsy of a drug withdrawal, on clearing dense drug-patent thickets, on how a survey change sheds light on iatrogenic opioid use disorder and on being tethered. Supplement to the New England Journal of Medicine, Vol. 391, No. 23.