Jan 27 2025 30 mins 2
In this episode, we're tackling a question I’ve been hearing a lot: What happens if you want to stop your GLP-1 medication (like Ozempic, Wegovy, Mounjaro, Zepbound, or Saxenda)? Whether you’re making this decision voluntarily or because circumstances force it, I’ll walk you through evidence-based strategies to minimize weight regain and ensure the best outcomes.
Here’s what I’ll cover today:
- What happens when you stop GLP-1 medications?
- GLP-1s are not just weight loss tools; they treat a chronic disease—obesity.
- Weight regain after stopping is common and tied to metabolic and hormonal adaptations.
- What research tells us about this transition:
- The STEP-1 Extension Trial showed patients regained about two-thirds of the weight they lost after stopping semaglutide, even with lifestyle interventions.
- A Diabetes, Obesity and Metabolism study highlights that weight regain is a natural metabolic response, not a failure of willpower.
- Why long-term GLP-1 use is often recommended:
- Think of GLP-1s like treatment for other chronic diseases, such as diabetes or hypertension. For most people, ongoing therapy is necessary for sustained benefits.
- Evidence-based strategies for transitioning off GLP-1s:
- Gradual tapering: Slowly reduce your dose under medical supervision.
- Focus on nutrition: Increase protein intake and monitor your eating habits closely.
- Prioritize physical activity: Incorporate resistance training to preserve muscle and support your metabolism.
- Use psychological tools: Employ CBT or other techniques to handle emotional eating and cravings.
- Consider adjunct therapies: Discuss options like metformin with your doctor.
- Key takeaway:
Transitioning off GLP-1s is not one-size-fits-all. It requires close collaboration with your healthcare provider, a strong emphasis on lifestyle habits, and ongoing psychological support. Whatever path you choose, remember this journey is about long-term health, not just weight loss.
🎧 If you’re looking for guidance on building resilience and consistency to create your healthiest lifestyle, whether you’re on or off GLP-1 medications, check out my coaching program, Best Weight, on my website: www.sashahighmd.com/bestweight.
References from today’s episode:
Copenhagen study on tapering off GLP-1s: Learn more
