Jan 28 2025 11 mins 7
Episode 120. Ketamine for Benzodiazepine-Resistant Status Epilepticus – A Game-Changer?
In this episode of The Pharm So Hard Emergency Medicine Podcast, host Jimmy Pruitt, PharmD, BCPS, BCCCP, BCEMP dives deep into an exciting new study exploring ketamine as a rescue agent for benzodiazepine-resistant status epilepticus. Traditionally, managing refractory seizures often requires intubation, high-dose propofol, or other antiepileptics. But could ketamine provide rapid and effective seizure control in these critical moments?
Jimmy discusses key findings from the study, practical implications for the ED, and how this data could influence your choice of induction agents during intubation. Plus, he shares valuable clinical pearls and caveats when considering ketamine use in different patient populations.
00:00 Introduction
02:16 The Clinical Dilemma: Benzodiazepine-Resistant Status Epilepticus
03:39 Introducing the Study: Ketamine as a Rescue Drug
05:16 Key Findings: Rapid Seizure Termination
06:05 Safety and Dosing Insights
06:42 Clinical Implications: Ketamine in ED Practice
07:05 Caveats and Patient Populations
07:55 Conclusion
