Core EM - Emergency Medicine Podcast

Show Notes

Table of Contents

0:00 – Introduction

0:41 – Overview

1:10 – Types of Necrotizing Fasciitis

2:21 – Pathophysiology & Risk Factors

3:16 – Clinical Presentation

4:06 – Diagnosis

5:37 – Treatment

7:09 – Prognosis and Recovery

7:37 – Take Home points

Introduction

• Necrotizing soft tissue infections can be easily missed in routine cases of soft tissue infection.


• High mortality and morbidity underscore the need for vigilance.

Definition

• A rapidly progressive, life-threatening infection of the deep soft tissues.


• Involves fascia and subcutaneous fat, causing fulminant tissue destruction.


• High mortality often due to delayed recognition and treatment.

Types of Necrotizing Fasciitis

• Type I (Polymicrobial)
  
  
  
  • Involves aerobic and anaerobic organisms (e.g., Bacteroides, Clostridium, Peptostreptococcus).
  
  
  • Common in immunocompromised patients or those with comorbidities (e.g., diabetes, peripheral vascular disease).
  
  
  
  


• Type II (Monomicrobial)
  
  
  
  • Often caused by Group A Streptococcus (Strep pyogenes) or Staphylococcus aureus.
  
  
  • Can occur in otherwise healthy individuals.
  
  
  • Vibrio vulnificus (associated with water exposure) is another example.
  
  
  
  


• Fournier’s Gangrene (Subset)
  
  
  
  • Specific to perineal, genital, and perianal regions.
  
  
  • Common in diabetic patients.
  
  
  • Higher mortality, especially in females.
  
  
  
  

Pathophysiology

• Spread Along Fascia
  
  
  
  • Poor blood supply in fascial planes allows infection to advance rapidly.
  
  
  • Tissue ischemia worsened by vascular thrombosis → rapid necrosis.
  
  
  
  


• High-Risk Patients
  
  
  
  • Diabetes with vascular compromise.
  
  
  • Recent surgeries or trauma (introducing bacteria into deep tissue).
  
  
  • Immunosuppression (e.g., cirrhosis, malignancy, or immunosuppressive meds).
  
  
  • NSAID use may mask symptoms, delaying diagnosis.
  
  
  
  

Clinical Presentation

Early Signs & Symptoms

• Severe Pain out of proportion to exam findings.


• Erythema (often with indistinct borders).


• Fever, Malaise (systemic signs of infection).


• Rapid progression with possible color changes (red → purple).


• Bullae Formation (fluid-filled blisters) and skin necrosis/gangrene.


• Crepitus in polymicrobial cases (gas production in tissue).

Late-Stage Signs

• Systemic toxicity: hypotension, multi-organ failure if untreated.

Diagnosis

• Clinical Suspicion Is Key
  
  
  
  • Pain out of proportion, rapid progression, systemic signs.
  
  
  • The “finger test” (small incision to explore fascial planes).
  
  
  
  


• Surgical Consultation
  
  
  
  • Early surgical exploration is often the definitive diagnostic step.
  
  
  
  


• Lab Tests
  
  
  
  • LRINEC Score (CRP, WBC, Hemoglobin, Sodium, Creatinine, Glucose) to stratify risk.
  
  
  • Not definitive but can guide suspicion.
  
  
  
  


• Imaging
  
  
  
  • CT scan may reveal gas in tissues, fascial edema, or muscle involvement.
  
  
  • Must not delay surgical intervention if clinical suspicion is high.
  
  
  
  

Treatment Principles

• Immediate & Aggressive Surgical Debridement
  
  
  
  • Often multiple surgical procedures are required as necrosis progresses.
  
  
  • Debridement back to healthy tissue margins.
  
  
  
  


• Empiric Broad-Spectrum Antibiotics
  
  
  
  • Cover gram-positive (including MRSA), gram-negative, and anaerobes.
  
  
  • Examples include:
    
    
    
    • Vancomycin or Linezolid (for MRSA).
    
    
    • Piperacillin-tazobactam or Carbapenems (for gram-negative & anaerobes).
    
    
    • Clindamycin (to inhibit bacterial toxin production).
    
    
    
    
  
  
  • Adjust based on culture results later.
  
  
  
  


• Adjunct Therapies
  
  
  
  • Hyperbaric Oxygen Therapy (if available) for resistant cases.
  
  
  • Evidence is mixed; not universally accessible.
  
  
  
  


• Supportive Care
  
  
  
  • Intensive monitoring, often in an ICU setting.
  
  
  • Fluid resuscitation & vasopressors for septic shock.
  
  
  
  

Prognosis & Disposition

• High Mortality Rate
  
  
  
  • Influenced by infection site, patient’s baseline health, and speed of intervention.
  
  
  
  


• Importance of Rapid Intervention
  
  
  
  • Early recognition, aggressive surgery, and antibiotics improve survival.
  
  
  
  


• Long-Term Considerations
  
  
  
  • Patients may require extensive rehabilitation.
  
  
  • Reconstructive surgery often needed for tissue deficits.
  
  
  
  


• Disposition
  
  
  
  • Operative management is mandatory; patients do not go home.
  
  
  • Critical care admission is typical for hemodynamic monitoring and support.
  
  
  
  

Five Key Take-Home Points

• High Suspicion Saves Lives: Recognize severe pain out of proportion as a critical red flag.


• Know Your NF Types & Risk Factors: Type I polymicrobial vs. Type II monomicrobial, plus subsets (Fournier’s).


• Clinical Diagnosis Above All: LRINEC and imaging help, but timely surgical exploration is paramount.


• Combined Surgical & Medical Therapy: Early debridement + broad-spectrum antibiotics (including toxin inhibition) is lifesaving.


• Extended Recovery & Mortality Risks: High mortality if missed or delayed. Expect prolonged rehab and possible multiple surgeries.

Resources & Further Reading

• LRINEC Score Calculator


• EMCrit – Necrotizing Fasciitis