The Proof with Simon Hill

Episode #335. Struggling to keep weight off long term? Learn the science behind successful fat loss and maintenance with experts Kevin Maki, PhD, and Carol Kirkpatrick, PhD. In this episode, we discuss evidence-based strategies for losing body fat and keeping it off, while exploring the role of nutrition, exercise, and pharmacological interventions.

You’ll learn about the impact of protein and fibre on hunger and satiety, the benefits of regular exercise for insulin sensitivity, and the potential role of medications like GLP-1 agonists. Dr Maki and Dr Kirkpatrick also share insights on the challenges of maintaining weight loss and how to make lasting changes for better health.

Specifically, we discuss:

• Introductions (00:00)


• Carol’s Journey into Nutrition and Research Development (04:27)


• Kevin’s Path in Cardiometabolic Health Research (11:53)


• The Importance of Observational Studies in Nutrition (14:59)


• Understanding Dietary Fats and Cardiometabolic Health (19:49)


• Public Health Nutrition: Current Challenges and Opportunities (31:55)


• Exploring Obesity and Its Impact on Metabolic Health (43:19)


• How Exercise Enhances Insulin Sensitivity (53:35)


• The Link Between Insulin Resistance and Ectopic Fat (55:01)


• Weight Loss Challenges: Why It’s So Hard to Keep the Weight Off (01:01:05)


• How GLP-1 Agonists Are Transforming Obesity Treatment (01:04:02)


• Behavioural Aspects of Obesity: Understanding the Psychology (01:11:22)


• The 30-30-30 Study: A New Approach to Sustainable Weight Loss (01:24:44)


• Cholesterol, Fibre, and Cardiovascular Health (01:44:02)


• Protein Supplements and How They Affect Digestion (01:46:56)


• Dietary Patterns and Regulating Appetite for Better Health (01:49:23)


• Exploring the 30-30-30 Framework for Weight Loss (01:51:49)


• How Protein Sources Influence Metabolic Health (01:57:53)


• Carbohydrate Quality vs. Restriction: What Matters More? (02:14:57)


• Exercise for Weight Maintenance and Long-term Health (02:27:12)


• The Future of Nutrition Research and Public Health (02:30:25)


• Final Thoughts (02:35:10)

Connect with Kevin Maki, PhD on LinkedIn and at https://www.mbclinicalresearch.com/. Connect with Carol Kirkpatrick, PhD on Twitter/X and LinkedIn.

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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