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106. The Science of Skin Aging & Peptides: How to Reverse the Clock with Alessandra Zonari


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Feb 25 2025 30 mins   5
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Are you frustrated with trying countless skincare products that promise anti-aging results but don't seem to work? In today's episode, I'm sitting down with scientist and skincare innovator Alessandra Zonari to uncover the fascinating connection between skin health and overall longevity. We explore how our skin's aging process starts at the cellular level and why addressing "zombie cells" could be the key to maintaining youthful, healthy skin. Whether you're dealing with premature aging, inflammation, or just want to understand how to better care for your skin, this conversation reveals groundbreaking research about peptides and their role in skin regeneration.

Key Points:

  • Understanding the skin as our largest organ and its crucial role in overall health - Alessandra explains how skin inflammation can contribute to age-related diseases and why maintaining skin health is about more than just aesthetics

  • The science behind skin aging - Learn when major changes start occurring (around age 30) and how accumulating cellular damage leads to visible signs of aging like sagging and thinning skin

  • Demystifying peptides - Get the facts about these powerful molecules, how they work to repair skin damage, and why not all peptide products are created equal when it comes to absorption

  • The truth about microneedling - Discover how this technique can enhance product absorption and what needle size is safe for at-home use

  • The "zombie cell" phenomenon - Understanding what these senescent cells are and how they contribute to skin aging and inflammation

  • Practical skincare solutions - Learn about targeted products that address skin aging at the cellular level and how to incorporate them into your routine

The science of skincare is evolving, and it's clear that taking care of our skin goes far beyond surface-level treatments. By understanding the cellular mechanisms of aging and implementing targeted solutions, we can not only improve our skin's appearance but potentially impact our overall health and longevity.

Remember to check out OneSkin.co and use code "drmeg" for 15% off to experience these science-backed solutions for yourself.

How to Connect with Dr. Meg:

Our Guest:

Alessandra Zonari

Website: https://www.oneskin.co

This content is for educational purposes only and should not be taken as medical advice. Always consult with a healthcare professional before starting any new diet or exercise program.

This podcast is for women in perimenopause and beyond who are struggling with fatigue, brain fog, bloating, weight loss resistance, and unpredictable hormones. If you’re dealing with exhaustion, low energy, digestive discomfort, or hormone imbalances, you’ll learn how to support your metabolism, balance hormones naturally, beat IBS and bloating, and finally break through stubborn weight gain. Discover science-backed strategies to optimize digestion, improve gut health, and manage perimenopause symptoms—without restrictive diets or endless supplements. Whether it’s addressing estrogen dominance, blood sugar balance, or adrenal fatigue, this podcast gives you the tools to take control of your health and feel vibrant again. If you are enjoying the show, please subscribe and leave a review or share it with a friend.

If you listen to any of the following shows, we're sure you'll like ours too!

Pursuit of Wellness with Mari Llewellyn, Everyday Wellness with Cynthia Thurlow, Just Ingredients Podcast, Longevity with Nathalie Niddam, Wellness Mama, The Dr. Josh Axe Show, Ancient Health Podcast, The Model Health Show, Grounded Wellness By Primally Pure, Be Well By Kelly Leveque, The Hormone Solution with Karen Martel, The Dr. Hyman Show, The Thyroid Fixer with Dr. Amie Hornaman, Treated with Dr. Sara, Well Beyond 40 with JJ Virgin, Better! with Dr. Stephanie, Energized with Dr. Mariza

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