May 19 2024 39 mins
We Love Science podcast celebrates our 50th episode with a discussion all about the hopes and progress of CRISPR clinical trials. Before a new drug, therapy, vaccine, or medical device is approved for general use by the public, its safety and effectiveness are evaluated in a series of tests on volunteers. These Clinical Trials progress in 3 successive phases with each phase designed to answer specific questions about the product under evaluation. Questions can include: What side effects does it cause? What is the lowest effective dose? What is the highest safe dose? Does it improve patients’ quality of life? Is it an effective cure for the disease in question? How does it compare to the current treatments (if any are available) for that particular disease?
Currently, only one CRISPR gene therapy, Casgevy, is approved for public use. It is approved in several countries to treat the blood disorders, Sickle Cell Disease and Beta Thalassemia. However, many CRISPR clinical trials are still ongoing; they span ~ 10 major disease categories and occupy every clinical trial phase. In this episode, we discuss the successes and challenges of CRISPR clinical trials to cure HIV/AIDS, Cardiovascular disease, and others.
Tune in to learn more about:
· What questions do successive clinical trial phases answer?
· How can CRISPR technology cure HIV/AIDS?
· The results for the hereditary amyloidosis treatment, which is now in phase III of clinical trials
· Listener question: An update for Sickle Cell Disease CRISPR treatments
For more information on this topic, visit our website: welovesciencepodcast.com
Useful Links: US and EU clinical trials databases:
https://euclinicaltrials.eu/?lang=en
Jump directly to the next episodes in the CRISPR series:
Catch up on the previous CRISPR episodes:
- Ep 35: The first CRISPR Chronicles episode: How CRISPR gene therapy is bringing hope to the world
- Ep 38: A foundational discussion explaining the secret behind CRISPR gene therapy
- Ep 41: A look into the ups and downs of how the CRISPR saga developed
- Ep 47: The CRISPR Cure for Sickle C
Support the Show: WeLoveSciencePodcast.com
Reach out to Fatu:
www.linkedin.com/in/fatubm
Twitter: @thee_fatu_b
and [email protected]
Reach out to Shekerah:
www.linkedin.com/in/shekerah-primus
and [email protected]
Music from Pixabay: Future Artificial Intelligence Technology 130 by TimMoor
Music from https://freemusicarchive.org/music/Scott_Holmes: Hotshot by ScottHolmesMusic