Feb 21 2025 12 mins
Why aren't GLP-1 medications working for everyone?
You may be frustrated that semaglutide or tirzepatide isn't helping you lose weight like it has for others. The problem might not be your diet or willpower - it could be genetic.
Discover how a single gene called TCF7L2 may be sabotaging your weight loss efforts with GLP-1 medications, and what you can do about it.
BY THE TIME YOU FINISH LISTENING, YOU'LL DISCOVER:
- Why 10-15% of people may be "non-responders" to GLP-1 agonists for weight loss
- The gene that could impact the effectiveness of GLP-1
- Strategies to overcome genetic resistance to GLP-1 medications
This episode could be a game-changer if you've been struggling with weight loss despite using GLP-1 agonists.
RESEARCH ARTICLES:
- Efficacy And Safety Of Semaglutide For Weight Loss In Adults With Overweight Or Obesity
- A review of receptor interactions and co-stimulation, Peptides
- Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
When you finish listening, I'd love to hear your biggest takeaway from today’s episode. Take a screenshot of you listening on your device, share it to your Instagram stories and tag me, @drtamarlawful!
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