Featuring articles on heart failure and obesity, oral anticoagulation during TAVI, hemophilia A, hereditary angioedema, and tuberculosis; a review article on sport-related concussion; a case report of a man with syncope, ankle swelling, and abnormal chest imaging; and Perspectives on e-cigarettes at the Supreme Court, on providing interstate telehealth abortion services to patients in restrictive states, on listening to TikTok, and on what is the relative value of a baby. Supplement to the New England Journal of Medicine, Vol. 392, No. 5.