Night Science

Mar 10 2025 72 ep. 37 mins 272

Night Science Podcast artwork

Where do ideas come from? In each episode, scientists Itai Yanai and Martin Lercher explore science's creative side with a leading colleague. New episodes come out every second Monday.

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71 | Victor Ambros and the unique ways we perceive wonder

Mar 10 2025 35 mins

Victor Ambros, newly awarded the Nobel Prize for his discovery of microRNA, is a developmental biologist at the University of Massachusetts Medical School. In this episode, we explore improvisational science – the dynamic, collaborative process where researchers build on each other’s ideas using a "yes, and…" approach. We discuss the constant need to reframe and refine scient

70 | Meghan O’Rourke on being the artist and their caretaker

Feb 17 2025 45 mins

Meghan O'Rourke, acclaimed author of The Invisible Kingdom, poet, and Yale professor, joins us to explore the parallels between creative writing and scientific discovery. She describes how deep immersion in a project attracts unexpected insights, and she introduces Night Poetry and Day Poetry, inspired by our concepts of Night Science and Day Science—where night represents raw cr

69 | Keith Yamamoto and the freedom to fail

Jan 27 2025 40 mins

Keith Yamamoto, professor and science policy leader at UCSF, discusses with us how modern science became trapped in a system that discourages creative risk-taking. Keith contrasts academia's fear of failure with Silicon Valley's acceptance of it as just another day at the office. We also talk about Keith’s introduction of a new NIH grant category specifically for paradigm-challen

68 | Peter Godfrey-Smith and middle class science

Jan 14 2025 33 mins

Peter Godfrey-Smith, a Professor of the Philosophy of Science at the University of Sydney, explores with us the differences between creativity in science and philosophy. While philosophers speculate unconstrainedly, scientists must balance creative thinking with the need for empirical testing and within our fields’ paradigms – if you mention the “Lamarck” word at a bar full

67 | A hypothesis is a liability

Dec 16 2024 39 mins

In this episode, Itai and Martin delve into the interplay between hypothesis-driven and exploratory research, drawing on insights from past guests of the Night Science Podcast. They discuss how being focused on a single hypothesis can prevent us from making discoveries, while emphasizing the value of open-ended exploratory analyses—often dismissed as “fishing expeditions.” Th

66 | Michael Fischbach and the scientific decision tree

Nov 25 2024 50 mins

In this episode, Stanford professor Michael Fischbach discusses insights from his course on how to choose meaningful research problems. Highlights include: - Invest time in problem selection: Spend more time upfront selecting the right research problem. - Date ideas: Before settling on an idea, explore multiple alternatives without emotional attachment. - Fixed vs. floating paramet

65 | James Kaufman and the art of creativity maintenance

Nov 04 2024 30 mins

James Kaufman, Professor of Educational Psychology at the University of Connecticut, discusses the psychological underpinnings of creative thinking with Itai & Martin. Together, we delve into the complex nature of creativity, exploring its roots as both a trait and a skill that can be nurtured. We examine the role of personality traits in creativity, the impact of interdiscipli

64 | Robert Weinberg and the perils of being a Fachidiot

Sep 30 2024 42 mins

MIT's Bob Weinberg is perhaps the world's most prominent cancer researcher. In this episode, Bob emphasizes that true innovation often comes from blending ideas from different fields – a synthesis that transcends the boundaries of one's primary area of research. We discuss the vital role of human interaction, with many scientific breakthroughs coming from informal collaborations

63 | Manu Prakash and how the discovery changes you

Sep 09 2024 44 mins

Manu Prakash is a professor of bioengineering at Stanford University, asking biological questions with insights from physics. His most widely known contribution is the FoldScope, a $1-microscope made from paper and a lens – 2 million copies of this have been distributed to would-be scientists around the world. In this episode, Manu emphasizes how science is a sense of wonder and

62 | Dianne Newman and the visceral and intentional sides of science

Aug 19 2024 40 mins

Dianne Newman – a molecular microbiologist at CalTech – is a professor both in Biology and Geology. In this episode, she encourages young scientists to pursue questions to which they have a visceral connection, rather than following popular trends. In its search for fundamental truths guided by our inner biases and preferences, Dianne likens scientific curiosity to artistic exp