Touching Base

Apr 26 2024 4
Touching Base Podcast artwork

Touching Base is the dynamic new podcast series from the Editors of GEN (Genetic Engineering & Biotechnology News). Each week, Senior Editors Kevin Davies, Julianna LeMieux, Alex Philippidis, Jonathan Grinstein, Uduak Thomas, and Fay Lin delve into emerging stories, exchange ideas, and debate the latest trends in biotech plus talk to some of the leading voices in the industry about what's now and next. Start listening today!
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DNA Day: Deep Dive

Apr 26 2024 47 mins  
Episode 19 (April 26, 2024): This week, the GEN editors celebrated DNA Day by sharing some stories about their favorite observations and applications of DNA research. Featuring Kevin Davies, PhD (Editorial Director, GEN), John Sterling (Editor in Chief, GEN), Uduak Thomas (Senior Editor, GEN), Alex Philippidis (Senior Business Editor, GEN), Fay Lin, PhD (Senior Editor, GEN Bio

How Biotechs Are Plugging AI into Drug Discovery Problems

Apr 19 2024 22 mins  
Episode 18 (April 19, 2024):    Biology’s exploding data streams continue to leverage artificial intelligence (AI) tools to streamline drug development. How do we define AI in drug discovery? Who are notable players in the space? How do humans fit into these growing computational pipelines?   This week, Jonathan Grinstein, PhD (Senior Editor, GE

Launch of Nvelop Therapeutics for Delivery of Genetic Cargo, AACR Recap

Apr 12 2024 34 mins  
Episode 17 (April 12, 2024):    This week, the GEN editors discuss the launch of Nvelop Therapeutics, a new start-up leveraging approaches developed by gene editing pioneers David Liu, PhD, and J. Keith Joung, MD, PhD, to advance delivery of genetic cargo. The GEN editors also recap highlights from the American Association for Cancer Research (AACR) annual

Dried Blood COVID Dx, Cryo-Shocked Tumor Cell Delivery Vehicles, Verve Halts Trial, Iambic Starts Trial, and Diagonal Therapeutics Launches

Apr 05 2024 31 mins  
Episode 16 (April 5, 2024): This week, the GEN editors discussed deep proteome profiling of home-sampled dried blood spots to assess the effects of SARS-CoV-2 in mildly symptomatic or asymptomatic, rapid liquid nitrogen treatment for converting tumor cells into carriers for gene editing tools that target cancer in vivo, Verve Therapeutics’ pausing of a clinical trial due to a ser

AI in Drug Discovery and Precision Medicine: Nvidia GTC and Precision Med TRI-CON

Mar 29 2024 36 mins  
Episode 15 (March 29, 2024): From the expansion of Nvidia's generative artificial intelligence (AI) platform for drug discovery to AI notetakers that coach doctors to be more human, the GEN editors discuss the latest news in AI from two conferences in California: Nvidia GTC (San Jose) and Precision Med TRI-CON (San Diego). Featuring Alex Philippidis (Senior Business Edito

Optimizing Nanoparticles and Messenger RNAs with Multiple “Tails”

Mar 22 2024 19 mins  
Episode 14 (March 22, 2024): This week, the GEN editors cover identifying receptors and proteins for cellular uptake and intracellular processing of nanoparticles, and a new mRNA structure by adding multiple “tails” to the molecules that boosted mRNA activity levels in cells by 5 to 20 times.  Featuring Jonathan D. Grinstein, PhD, (Senior Editor, GEN), Uduak Thom

NanoString Finds a Buyer, Slide Tags Enter in Early Access as Curio Trekker, Cellares Unveils Cell Therapy Manufacturing Platform

Mar 15 2024 24 mins  
 Episode 13 (March 15, 2024): This week, the GEN editors discussed business news from NanoString, Curio, and Cellares. Featuring Alex Philippidis (Senior Business Editor, GEN), Uduak Thomas (Senior Editor, GEN), Jonathan Grinstein, PhD, (Senior Editor, GEN), and moderated by Corinna Singleman, PhD, (Managing Editor, GEN and IPM). Listed below are key references to th

International Women’s Day, Nanoparticles and Delivery, Novo Nordisk’s Expansion, and Organoids for Congenital Conditions

Mar 08 2024 23 mins  
Episode 12 (March 8, 2024): Featuring Julianna LeMieux (Deputy Editor-in-Chief, GEN), Uduak Thomas (Senior Editor, GEN), and Alex Philippidis (Senior Business Editor, GEN), moderated by Fay Lin (Senior Editor, GEN Biotechnology) This week, the GEN editors cover a recent interview with the Lost Women of Science, advances in delivery with lipid nanoparticles, Novo Nordisk’s ex

Moderna Gets Back to Its Roots, Form Bio and Ginkgo Bioworks Team Up, and Under-the-Radar Rare Autoimmune Diseases

Mar 01 2024 26 mins  
Episode 11 (March 1, 2024): After being diverted by the SARS-CoV-2 pandemic to develop and manufacture COVID-19 vaccines, Moderna gets back to advancing rare disease mRNA therapeutics; a look at rare autoimmune diseases that fly below the public radar; Form Bio announced a partnership with Ginkgo Bioworks to bring their AI out of the computer and into gene therapy production by opt

Prime Editing for Isogenic iPSCs, PRINT, Universal In Vivo CAR T Editing, Biogen Q4 Results Disappoint; Andrea Choe

Feb 23 2024 43 mins  
Episode 10 (February 23, 2024): Researchers from Francis Collins’ lab developed an efficient CRISPR prime editing protocol to generate isogenic-induced pluripotent stem cell (iPSC) lines carrying heterozygous or homozygous alleles for putatively causal single nucleotide variants. An RNA-based system known as PRINT can create and introduce site-specific, safe, and stable transgene