Alzheimer’s Disease And Dementia – Johns Hopkins Medicine Podcasts

Mar 11 2024 10 ep. 1 mins 6

Alzheimer’s Disease And Dementia – Johns Hopkins Medicine Podcasts artwork

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Can a novel way to get antibodies into the brain help Alzheimer’s disease? Elizabeth Tracey reports

Mar 11 2024 1 mins

Something called the blood brain barrier prevents many things, including most drugs, from entering your brain. Now a new study that disrupts the barrier using ultrasound seems to have shown that antibodies to treat Alzheimer’s disease can gain entry this way. Geriatrics expert Lolita Nidadavolu at Johns Hopkins says she has concerns. Nidadavolu: With aging there is disruption, th

Only a small percentage of people are candidates for monoclonal antibodies to treat Alzheimer’s disease, Elizabeth Tracey reports

Mar 11 2024 1 mins

Monoclonal antibodies for Alzheimer’s disease, like the drug called Aduhelm, attach to aberrant proteins thought to be one cause of the disease, but they only stand to benefit a small number of the people who might be at risk. That’s according to Lolita Nidadavolu, a geriatrics expert at Johns Hopkins. Nidadavolu: Ten percent of all their population that had mild cognitive impa

Who is a candidate for monoclonal antibodies for Alzheimer’s disease? Elizabeth Tracey reports

Mar 11 2024 1 mins

Aduhelm is a type of drug called a monoclonal antibody, and it’s used to remove some of the aberrant proteins thought to cause Alzheimer’s disease. Lolita Nidadavolu, a geriatrics expert at Johns Hopkins, says there is much to consider when someone thinks they may be a candidate for these drugs. Nidadavolu: It’s a very individualized question to ask someone about side effects

Should women use sildenafil to reduce their risk of Alzheimer’s disease? Elizabeth Tracey reports

Mar 11 2024 1 mins

Men who reported taking sildenafil for erectile dysfunction also had a reduced risk for Alzheimer’s disease, a recent study looking at a large number of medical records found. What about women? Johns Hopkins geriatrics expert Lolita Nidadavolu, who wrote an editorial on the study, says she would not recommend this right now. Nidadavolu: For women you're seeing this vasodilation t

Would sildenafil work to reduce Alzheimer’s disease risk in women? Elizabeth Tracey reports

Mar 04 2024 1 mins

Sildenafil, taken for erectile dysfunction, seems to have helped reduce Alzheimer’s disease risk in men. Would the drug have the same impact on women, and what might the side effects look like? Lolita Nidadavolu, a geriatrics expert at Johns Hopkins and coauthor of an editorial on the study, says such a study is clearly needed. Nidadavolu: This study was mainly looking at men. It

How might sildenafil work to reduce Alzheimer’s risk? Elizabeth Tracey reports

Mar 04 2024 1 mins

Taking sildenafil for erectile dysfunction reduced the risk for developing Alzheimer’s disease, a study looking at medical records of over 260,000 found. Geriatrics expert Lolita Nidadavolu at Johns Hopkins and coauthor of an editorial on the study says there is a mechanism that makes sense. Nidadavolu: What we know about how PDE 5 inhibitors function is they are vasod

How often does sildenafil need to be taken to reduce the risk of Alzheimer’s disease? Elizabeth Tracey reports

Mar 04 2024 1 mins

Men who took sildenafil for erectile dysfunction experienced less Alzheimer’s disease than men who did not, a very large study looking at medical records found. One problem, says Lolita Nidadavolu, a Johns Hopkins geriatrics expert and coauthor of an editorial on the study, is it’s not possible to determine exactly what dose of the medicine was used. Nidadavolu: So they did fin

The erectile dysfunction drug sildenafil may reduce the risk of Alzheimer’s disease, Elizabeth Tracey reports

Mar 04 2024 1 mins

Sildenafil is used by men with erectile dysfunction, with a recent study examining medical records of men who used it finding they also developed Alzheimer’s disease less often. This is called an observational study, and it only can find an association at best. Geriatrics expert Lolita Nidadavolu at Johns Hopkins, who cowrote an editorial on the study, says the researchers did th

Can the erectile dysfunction drug sildenafil help stave off Alzheimer’s disease? Elizabeth Tracey reports

Mar 04 2024 1 mins

Examining the medical records of more than 265,000 men has revealed that those who took the erectile dysfunction drug sildenafil experienced a reduced rate of Alzheimer’s disease in comparison to those who did not. Lolita Nidadavolu, a geriatrics expert at Johns Hopkins and co-author of an editorial on the study, says if this finding is validated it could help many. Nidadavolu: T

There are two forms of dementia that are most common, Elizabeth Tracey reports

Jan 08 2024 1 mins

Dementia encompasses quite a few conditions, including Alzheimer’s but also frontotemporal, Lewy body, and vascular dementia, and others. Halima Amjad, a dementia expert at Johns Hopkins, says two of these types are seen most often. Amjad: We actually think that mixed dementia so having more than one cause to explain what's happening is second only to Alzheimer's. What separates