At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy

Jun 30 2016 11 ep. 22 mins 6

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy Podcast artwork

The conference will represent a unique forum to discuss the most recent and unpublished findings on the basic biology of replication fork perturbation and repair as well as on our current understanding of how replicative stress drives cancer and aging. Session topics will include: Basic mechanisms at the replication fork, Replication-repair interface, Replication fork remodeling, Structural and single molecule analysis of replication/repair, Replication-transcription interface, Replication-recombination interface Chromatin, replication and genome maintenance, Difficult-to-replicate loci and telomers, Replication stress in cancer onset and therapy.

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P. Burgers - The inner workings of the lagging strand maturation machinery

Jun 28 2016 22 mins

Peter Burgers, Washington University, St.Louis, speaks on "The inner workings of the lagging strand maturation machinery". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

P. Knipscheer - How does the Fanconi pathway promote unhooking of DNA interstrand crosslinks?

Jun 28 2016 22 mins

Puck Knipscheer, Hubrecht Institute, Utrecht, speaks on "How does the Fanconi pathway promote unhooking of DNA interstrand crosslinks?". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

T. Carr - Mechanisms of replication-associated genome rearrangement

Jun 28 2016 22 mins

Tony Carr, University of Sussex, Falmer, speaks on "Mechanisms of replication-associated genome rearrangement". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

D. Cortez - ETAA1 regulates ATR to maintain genome stability during DNA replication

Jun 28 2016 21 mins

David Cortez, Vanderbilt University, Nashville, speaks on "ETAA1 regulates ATR to maintain genome stability during DNA replication". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

P. Pasero - SAMHD1 processes stalled forks and links DNA replication stress to inflammation

Jun 28 2016 20 mins

Philippe Pasero, Institute of Human Genetics, Montpellier, speaks on "SAMHD1 processes stalled forks and links DNA replication stress to inflammation". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

W. Yang - Molecular gymnastics during DNA translesion synthesis

Jun 29 2016 24 mins

Wei Yang, NIDDK, NIH, Bethesda, speaks on "Molecular gymnastics during DNA translesion synthesis". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

J. Berger - Structural mechanisms for initiating DNA replication

Jun 29 2016 23 mins

James Berger, Johns Hopkins, Baltimore, speaks on "Structural mechanisms for initiating DNA replication". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

A. Constantinou - A FANCM protein interaction screen reveals a pyrimidine catabolism enzyme required to prevent cell-intrinsic DNA replication stress

Jun 29 2016 20 mins

Angelos Constantinou, Institute of Human Genetics, Montpellier, speaks on "A FANCM protein interaction screen reveals a pyrimidine catabolism enzyme required to prevent cell-intrinsic DNA replication stress ". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

I. Whitehouse - Coupling of gene enhancers and replication origins

Jun 29 2016 22 mins

Iestyn Whitehouse, Memorial Sloan-Kettering CC, New York, speaks on "Coupling of gene enhancers and replication origins". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

S. Mirkin - Mechanisms of genome instability mediated by interstitial telomeric sequences

Jun 30 2016 21 mins

Sergei Mirkin, Tufts University, Medford, speaks on "Mechanisms of genome instability mediated by interstitial telomeric sequences". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.