Basics to Brilliance: Haematology Podcast

May 26 2024 1

Basics to Brilliance: Haematology Podcast artwork

Welcome to Basics to Brilliance, the Haematology podcast created to supplement & bolster your knowledge for the FRCPath Part 1.
Featuring a two way, non-didactic conversational-style Q&A between the SpR and SHO, this podcast will be your pocket companion no matter where you are.

We aim to cover:
- Malignant and non-malignant topics- The whole syllabus for FRCPath part 1- Review UK guidelines - Go into science/lab detail- Discuss how guidelines often translate into practice- Review and appraise hallmark trials - Discuss future research directions
All readily accessible and completely free of charge!

For every budding haematologist out there, we hope this podcast aids you in your endeavours and fills you with interest and excitement for the brilliant world of Haematology.

Warmest Regards,
Dr. Everden
Dr. Fasey
Dr. Jafri

Note: Guidelines discussed are the most recent as of late 2023/early 2024

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Polycythemia Rubra Vera

May 26 2024 72 mins

Polycythaemia- red cell #Erythrocytosis – in red cell massAbsolute Erythrocytosis- M: Hct >0.60 or >0.52 + RCM >25% of mean- F: Hct >0.56 or >0.48 + RCM >25% of meanApparent Erythrocytosis- Men: Hct >0.52 + normal RCM- Women: Hct >0.48 + normal RCMRelative erythrocytosis-Normal RCM + Reduced plasma volume (pathological dehydration)M>FMedian >60yo2' P

Secondary CNS Lymphoma

May 12 2024 37 mins

- Synchronous CNS and systemic lymphoma at initial presentation (treatment-naïve; TN-SCNSL)- CNS relapse without recurrent systemic lymphoma (relapsed isolated CNS lymphoma; RI-SCNSL)- Relapsed concomitant systemic and CNS disease following treatment for systemic lymphoma (RC-SCNSL) Generally hybrid disease Investigations- MRI Head w gadolinium- PET-CT- Testicular US (blood testes

Primary CNS Lymphoma

Apr 28 2024 69 mins

CNS Lymphomas1% of all NHL3% of all Brain tumoursMost common subtype (90%) is DLBCL Clinical division:1. 1* CNS lymphoma, 2. 2* CNS lymphoma- TN-SCNSL- RI-SCNSL- RC-SCNSL3. Immune deficiency assoc- HIV; better prog. Presentation: - SOL Sx - Raised ICP: morning headaches w N+V- Neuropsych, Behavioural, Memory, Language- Focal motor + Stroke Sx- Seizures- Visual Sx and uveit...

Chronic Monomyelocytic Leukemia (CMML)

Apr 14 2024 41 mins

Chronic MyeloMonocytic Leukemia (not CML)Persistently high monocyte count- 3 months Most frequent MDS/Myeloproliferative neoplasms – a cross between the twoMedian age 72Median survival 20-40 months Transformation to AML (15-30%) WHO definition of CMML:1. Excess monocytes- persistent over 3 months, ≥ 1 - Monocytes 10% of total WC count2. Dysplasia: morphological difference (bloo

Chronic Lymphocytic Leukemia (CLL)

Mar 31 2024 78 mins

Chronic Lymphocytic Leukemia (CLL)- Chronic Relapsing RemittingMost common leukemia in adultsIncurable but treatable*Remember Supportive Care*Median age of 72M > F80% incidentalSLL: lymphocytes in lymph nodes and spleen instead of blood Presentation: 1) Fatigue2) B symptoms3) High WC4) Cytopenias (Marrow infiltrate, AIHA, ITP, Hyposplenism)Rule out: Reactive (viral serology)- He