For patients with major depressive disorder (MDD), achieving remission is the penultimate therapeutic goal. Yet as many as two-thirds of patients do not achieve remission after initial treatment with a first-line antidepressant.(1) This neuroscienceCME Chart Review activity addresses clinician-based gaps that may contribute to underachievement of sustained remission in patients with MDD. Specifically, an index patient case will be used as the content foundation upon which expert faculty will engage in a provocative, consult-type exchange.