Epigenetics Podcast

Feb 27 2025 145 ep. 40 mins 221
Epigenetics Podcast artwork

Discover the stories behind the science!

  Science  Technology
RSS feed Share
Copy RSS


Subscribe on Podcast Addict


The Mechanism of ATP-dependent Remodelers and HP1 Gene Silencing (Geeta Narlikar)

Feb 27 2025 39 mins  
In this episode of the Epigenetics Podcast, we talked with Geeta Narlikar from UCSF about her work on chromatin remodeling, Heterochromatin Protein 1, and the molecular mechanisms that influence the genome. The conversation starts with a pivotal paper from the early days of Dr. Narlikars research career, titled "Distinct Strategies to Make Nucleosomal DNA Accessible," focused on tw

Polycomb Proteins, Gene Regulation, and Genome Organization in Drosophila (Giacomo Cavalli)

Feb 13 2025 44 mins  
In this episode of the Epigenetics Podcast, we talked with Giacomo Cavalli from the Institute of Human Genetics in Montpellier about his work on critical aspects of epigenetic regulation, particularly the role of Polycomb proteins and chromatin architecture. We start the Interview by talking about Dr. Cavalli's work on Polycomb function in maintaining chromatin states and how it r

The Interplay of Nutrition, Metabolic Pathways, and Epigenetic Regulation (Ferdinand von Meyenn)

Jan 23 2025 48 mins  
In this episode of the Epigenetics Podcast, we talked with Ferdinand von Meyenn from ETH Zürich about his work on the interplay of nutrition, metabolic pathways, and epigenetic regulation. To start Dr. Meyenn recounts his pivotal research on DNA methylation in naive embryonic stem cells during his time with Wolf Reick. He explains the dynamics of global demethylation in naive stem

Single-Molecule Adenine Methylated Oligonucleosome Sequencing Assay (SAMOSA) (Vijay Ramani)

Jan 09 2025 52 mins  
In this episode of the Epigenetics Podcast, we talked with Vijay Ramani from the Gladstone Institute about his work on Single-Molecule Adenine Methylated Oligonucleosome Sequencing Assay (SAMOSA). Our discussion starts with Vijay Ramani's impactful contributions to the field during his time in Jay Shendure's lab, where he worked on several innovative methods, including RNA proximit

Epigenetic Consequences of DNA Methylation in Development (Maxim Greenberg)

Dec 19 2024 44 mins  
In this episode of the Epigenetics Podcast, we talked with Maxim Greenberg from the Institute Jacob Monot about his work on epigenetic consequences of DNA methylation in development. In this interview we explore how Dr. Greenberg’s work at UCLA involved pioneering experiments on DNA methylation mechanisms and how this period was marked by significant collaborative efforts within

R-Loop Biology in Health and Disease (Natalia Gromak)

Dec 05 2024 29 mins  
In this episode of the Epigenetics Podcast, we talked with Natalia Gromak from the University of Oxford about her work on R-Loop biology in health and disease. In this interview Dr. Gromak delves into her significant research on transcription and RNA biology, particularly focusing on the molecular mechanisms involved at transcriptional pause sites. She describes her early work in u

The Menin-MLL Complex and Small Molecule Inhibitors (Yadira Soto-Feliciano)

Nov 21 2024 40 mins  
In this episode of the Epigenetics Podcast, we talked with Yadira Soto-Feliciano from MIT about her work on the Menin-MLL complex and the effect of small molecules on its stability in leukemia. We explore the pivotal moments that led her to cancer biology during her graduate studies, where her work included ground-breaking research on the role of the plant homeodomain Finger protei

Grant Writing in Academia and Industry – Tips for Success (Mary Anne Jelinek)

Nov 14 2024 39 mins  
In this episode of the Epigenetics Podcast, we talked with Mary Anne Jelinek Associate Director of R&D at Active Motif about writing and reviewing grants in academia and industry. Learn from Dr. Jelinek’s years of experience writing and reviewing grants and get her best advice and insight for success. Hear about similarities and differences in preparing grants in academia vs.

DNase Hypersensitive Sites and Chromatin Remodeling Enzymes (Carl Wu)

Oct 31 2024 55 mins  
In this episode of the Epigenetics Podcast, we talked with Carl Wu from John's Hopkins University about his work on nucleosome remodeling, histone variants, and the role of single-molecule imaging in gene regulation. Our discussion starts with Carl Wu sharing his first significant milestones, a paper in "Cell" and the serendipitous discovery of DNA hypersensitive sites, which trans

Epigenetic Mechanisms of Mammalian Germ Cell Development (Mitinori Saitou)

Oct 17 2024 39 mins  
In this episode of the Epigenetics Podcast, we talked with Mitinori Saitou from Kyoto University about his work on germ cell development, focusing on proteins like BLIMP1 and PRDM14, reprogramming iPSCs, and his vision to address infertility and genetic disorders through epigenetic insights. To start our discussion, Dr. Saitou shares the foundation of his research, which centers on