Geriatric Neuroscience Research

Studies:Spector A, Thorgrimsen L, Woods BO, Royan L, Davies S, Butterworth M, Orrell M. Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: randomised controlled trial. The British Journal of Psychiatry. 2003 Sep;183(3):248-54.Woods B, O'Philbin L, Farrell EM, Spector AE, Orrell M. Reminiscence therapy for dementia. Cochrane database of s

STUDY:Sattarov, R., Havers, M., Orbjörn, C. et al. Phosphorylated tau in cerebrospinal fluid-derived extracellular vesicles in Alzheimer’s disease: a pilot study. Sci Rep 14, 25419 (2024). https://doi.org/10.1038/s41598-024-75406-0Findings: This research paper investigates the potential of extracellular vesicles (EVs), tiny membrane-bound sacs secreted by cells, as biomarkers fo

Timeline0:00:00 Intro0:00:34 BPSD Guidelines Intro0:01:28 Agitation management: Non-pharmacologic & Pharmacologic0:03:27 Psychosis management: Non-pharmacologic & Pharmacologic0:04:22 Depression management: Non-pharmacologic & Pharmacologic0:05:16 Anxiety management: Non-pharmacologic & Pharmacologic0:05:45 Disinhibited Sexual expressions: Best scale0:06:10 Deprescr

STUDIES:Laws SM, Hone E, Gandy S, Martins RN. Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. Journal of neurochemistry. 2003 Mar;84(6):1215-36.Roses AD, Saunders AM. APOE is a major susceptibility gene for Alzheimer's disease. Current opinion in biotechnology.

STUDY:Woodham, R.D., Selvaraj, S., Lajmi, N. et al. Home-based transcranial direct current stimulation treatment for major depressive disorder: a fully remote phase 2 randomized sham-controlled trial. Nat Med (2024). https://doi.org/10.1038/s41591-024-03305-y

STUDIES:Rizzi L, Rosset I, Roriz-Cruz M. Global epidemiology of dementia: Alzheimer’s and vascular types. BioMed research international. 2014;2014(1):908915.Smits LL, van Harten AC, Pijnenburg YA, Koedam EL, Bouwman FH, Sistermans N, Reuling IE, Prins ND, Lemstra AW, Scheltens P, van der Flier WM. Trajectories of cognitive decline in different types of dementia. Psychological med

STUDY:Gallego-Rudolf J, Wiesman AI, Pichet Binette A, Villeneuve S, Baillet S, PREVENT-AD Research Group. Synergistic association of Aβ and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults. Nature Neuroscience. 2024 Sep 18:1-8.

STUDIES:Dobson R, Patterson K, Malik R, Mandal U, Asif H, Humphreys R, Payne M, Eng O, Huzzey L, Clare A, Green K. Eligibility for antiamyloid treatment: preparing for disease-modifying therapies for Alzheimer’s disease. Journal of Neurology, Neurosurgery & Psychiatry. 2024 May 15.Laurell AA, Venkataraman AV, Schmidt T, Montagnese M, Mueller C, Stewart R, Lewis J, Mundell C,

STUDIES:Xue C, Kowshik SS, Lteif D, Puducheri S, Jasodanand VH, Zhou OT, Walia AS, Guney OB, Zhang JD, Pham ST, Kaliaev A. AI-based differential diagnosis of dementia etiologies on multimodal data. Nature Medicine. 2024 Jul 4:1-3.Grigas O, Maskeliunas R, Damaševičius R. Early detection of dementia using artificial intelligence and multimodal features with a focus on neuroimaging: