Neurology And Neurosurgery – Johns Hopkins Medicine Podcasts

Nov 11 2024 10 ep. 1 mins 6.6k
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Skin isn’t the only place to sample to make a diagnosis of Parkinson’s disease, Elizabeth Tracey reports

Nov 11 2024 1 mins  
Skin biopsies can diagnose both Parkinson’s disease and other neurological conditions called prion diseases, recent studies show. Ted Dawson, Johns Hopkins Parkinson’s expert, predicts that soon, blood will supplant skin for detection of these incorrectly folded proteins. Dawson: We also know that you can detect it in the blood. What that means is we're going to be able to do b

Personalized treatment may soon come for Parkinson’s disease, Elizabeth Tracey reports

Nov 11 2024 1 mins  
More than 200,000 people in the US alone are diagnosed with Parkinson’s disease yearly, but it can be caused by multiple forms of a misfolded protein called alpha synuclein. Ted Dawson, a Parkinson’s expert at Johns Hopkins, says managing the condition will soon integrate which type of the protein an individual has. Dawson: Treatment of Parkinson's disease is going to come down

Some people with Parkinson’s disease will test negative with the best test yet, Elizabeth Tracey reports

Nov 11 2024 1 mins  
A type of test known as a seeding assay has been shown to be very good at diagnosing conditions like Parkinson’s disease, caused by a protein that folds incorrectly. Parkinson’s disease expert Ted Dawson at Johns Hopkins predicts these types of assays will become the new gold standard for diagnosis, yet a number of patients may not benefit. Dawson: In the largest paper done doi

What is it that causes a normal protein to fold differently and cause Parkinson’s disease? Elizabeth Tracey reports

Nov 11 2024 1 mins  
A protein called alpha synuclein is normally found in our bodies, but it’s also found in a misfolded form that’s known to cause Parkinson’s disease. A recent study shows a skin biopsy can help make the diagnosis. Johns Hopkins Parkinson’s disease expert Ted Dawson says one thing that’s still unknown is why exactly the protein misfolds. Dawson: There's a lot of work which

Parkinson’s disease is actually a few different clinical entities, Elizabeth Tracey reports

Nov 11 2024 1 mins  
Used to be Parkinson’s disease was thought of as a movement disorder, but now it’s known that as the condition progresses two different types of dementia can also emerge. Ted Dawson, a Parkinson’s expert at Johns Hopkins, says recent studies confirm that an aberrant protein known as alpha synuclein is behind it all. Dawson: The driving force in both is pathologic alpha synucl

A new way of diagnosing prion disease may also help in other diseases, Elizabeth Tracey reports

Nov 04 2024 1 mins  
Prions are misfolded proteins that can infect us and cause our normal proteins to fold incorrectly also, and they can be found in the skin, a new study reports. Ted Dawson, a Parkinson disease expert at Johns Hopkins, says this misfolded protein etiology is also seen in this much more common neurological disease.  Dawson: It's a real frame shift in the way we think about Parki

What is a prion and how does it cause disease? Elizabeth Tracey reports

Nov 04 2024 1 mins  
Prion diseases are caused in people when an aberrant form of a protein that is already in our bodies infects us, and causes the normal protein to fold like it, resulting in neurological disease. A new study found that one type of a prion disease could be accurately diagnosed with two or more skin biopsies. Johns Hopkins neurologist Ted Dawson explains. Dawson: All of us have the pr

Why is it that a disorder that affects the brain can be diagnosed with a skin biopsy? Elizabeth Tracey reports

Nov 04 2024 1 mins  
The rare brain disorder abbreviated CJD, for Creutzfeldt-Jakob disease, can be diagnosed with two or more skin biopsies, a recent study shows. Johns Hopkins neurologist Ted Dawson says the fact that what causes the disease, a particle smaller than a virus called a prion, can be found in the skin means dispersal is much broader than the brain. Dawson: What it suggests is that t

Making the diagnosis for a rare brain disease may now be easier, Elizabeth Tracey reports

Nov 04 2024 1 mins  
Skin biopsies have proven better at diagnosing the rare brain disease Creutzfeldt-Jakob, abbreviated CJD, than doing a spinal tap to obtain cerebrospinal fluid, a new study reports. Ted Dawson, a neurologist at Johns Hopkins, says this new test has multiple advantages. Dawson: This allows one to establish 1, the diagnosis. It can limit the need to have a pathologic diagnosis a

Diagnosing some neurologic diseases may now use a skin biopsy, Elizabeth Tracey reports

Nov 04 2024 1 mins  
Creutzfeldt-Jakob disease or CJD is a rare neurological condition that may initially look like dementia and that is ultimately fatal. It’s caused by something called a prion, which is smaller than a virus. Now a new study demonstrates that a skin biopsy done in two or more different places can make the diagnosis. Ted Dawson, a neurologist at Johns Hopkins, says this test cou