The Bio Report

Apr 09 2025 558 ep. 25 mins 550
The Bio Report Podcast artwork

The Bio Report podcast, hosted by award-winning journalist Daniel Levine, focuses on the intersection of biotechnology with business, science, and policy.

  Science  Business  Health & Fitness
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Bridging the Translational Divide in Healthcare AI

Apr 09 2025 27 mins  
The Zimin Institute for AI Solutions in Healthcare, a joint initiative between the Zimin Foundation and the Technion – Israel Institute of Technology, is seeking to accelerate the integration of AI into the life sciences. Although it is pursuing a wide range of opportunities from precision medicine to therapeutic discovery, its primary focus is on addressing real-world problems a

Seeking Long-Term Pain Relief from a Drug-Free Injection

Apr 02 2025 29 mins  
The search for non-opioid pain relievers opioids has focused on pharmaceutical alternatives including non-steroidal anti-inflammatories, antidepressants, and anticonvulsants. Brixton Biosciences is developing Neural Ice, an injectable frozen slurry that can degenerate nerves in targeted areas and provide pain relief for extended periods. The discovery capitalizes on unexpected find

Engaging Hard-to-Target Receptors with Antibodies that Activate

Mar 26 2025 39 mins  
Antibodies have been powerful tools for inhibiting a targeted protein. Abalone Bio is pursuing a new class of antibody therapies called activating antibodies that can regulate cellular processes and restore their balance. One aspect that makes these rare antibodies attractive is that they can target previously undruggable G protein-coupled receptors, allowing them to treat diseases

An Insider’s View of the Patent Fights that Shaped the Biotech Industry

Mar 19 2025 71 mins  
Jorge Goldstein trained for a career in molecular biology and biochemistry before becoming a patent attorney, a background that positioned him to help shape patent law for the biotech industry throughout his 40-year career. In his new book Patenting Life: Tales from the Front Lines of Intellectual Property and the New Biology, Goldstein offers a history of the biotech industry thro

Restoring Balance to the Immune System in Allergic Diseases

Mar 12 2025 28 mins  
Eosinophilic esophagitis is a progressive allergic disease characterized by difficulty swallowing and gastric reflux. It results from an elevated number of inflammatory immune cells in the walls of the esophagus. If left untreated, it can cause long-term complications, including scarring and difficulty swallowing. Revolo Biotherapeutics is developing a synthetic peptide therapy tha

Turning Natural Killers into Off-the-Shelf Therapies for Autoimmune Disease

Mar 05 2025 32 mins  
NK cells, part of the innate immune system, serve as the body’s first line of defense. These cells can recognize and kill abnormal or infected cells. As therapies, they have the advantage over CAR-T and other cell therapies because they can be used off-the-shelf without undergoing gene editing or other genetic modifications. They also don’t trigger cytokine storms, a common rea

Combining an Antibody and siRNA to Treat Hepatitis B

Feb 26 2025 29 mins  
More than a decade after the approval of a curative therapy for hepatitis C, hepatitis B has proven more challenging to tackle. Vir Biotechnology, in collaboration with Alnylam Pharmaceuticals, is developing a promising combination approach that marries Vir’s monoclonal antibody tobivibart with Alnylam’s siRNA elebsiran. We spoke to Mark Eisner, chief medical officer of Vir, ab

Looking at the Promise of GLP-1 Agonists Beyond Obesity

Feb 19 2025 22 mins  
While GLP-1 agonists have been all the rage in treating obesity, Coya Therapeutics sees potential for these therapies to address inflammatory diseases. In fact, Coya is developing its low-dose interleukin 2 in combination with several different agents. The belief is that its approach will address inflammation by targeting dysfunctional regulatory T cells. The company is pursuing mu

An Off-the-Shelf Cancer Vaccine Faces a Final Clinical Hurdle in NSCLC

Feb 12 2025 31 mins  
Though cancer vaccines have been an area of great promise, in practice they have faced several challenges because of the heterogeneity of tumors, the ability of the tumor microenvironment to suppress the immune system, and the challenges of producing a strong and sustained T-cell response. OSE Immunotherapeutics’ off-the-shelf cancer vaccine Tedopi has shown promising results in

A Nose for Attacking Brain Cancer

Feb 05 2025 8 mins  
One of the challenges in treating brain cancer and other diseases of the central nervous system is delivering therapeutics beyond the blood-brain barrier. NeOnc Technologies using a natural compound derived from essential oils in plants that not only can kill cancer cells, but can cross the blood-brain barrier. What’s more, it can transport other therapies as well. We spoke to Th