ToxChats©

Feb 03 2025 41 ep. 27 mins 20
ToxChats© Podcast artwork

The American College of Toxicology podcast program, ToxChats ©, reports on cutting-edge news in toxicological research from around the globe.

  Science  Education
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Career Path: Toxicologist in the Food Industry

Feb 03 2025 25 mins  
This podcast is part of a series on the different career paths in the field of toxicology. In this episode, we interview Dr. Alex Eapen on his career path to his current position as the Director of R&D Scientific & Regulatory Affairs – North America at Cargill. Dr. Eapen shares his experiences as a toxicologist in the food industry and the exciting opportunities this job

Changing Approaches to Getting Drug Candidates into First-in-Human Clinical Trials: A Case Study

Dec 18 2024 26 mins  
Not every drug that has reached human clinical trials has needed preliminary nonclinical studies to demonstrate safety. This podcast episode is a case study for replacing the use of animals during the safety testing that occurs prior to human clinical trials, in which our guest speaker reviews conversations with regulatory authorities regarding a modern nonanimal testing strategy u

Career Path: Pharmaceutical Consultant in the Field of Toxicology

Nov 04 2024 45 mins  
This ToxChats© episode is part of a series on the different career paths in the field of toxicology. In this episode, we interview Dr. Marcus Delatte on his career path to his current position as the Vice President of Regulatory Strategy at the consulting company, Allucent. Dr. Delatte also shares his experiences as a pharmaceutical consultant in toxicology.

3D Printing Emissions and Potential Health Effects from a Consumer Perspective

Sep 02 2024 18 mins  
In this podcast, recent findings from toxicological studies on the emissions produced during fused filament fabrication (FFF) 3D printing are discussed. The use of low-cost FFF 3D printers is on the rise in households, businesses, and educational settings, enabling the creation of 3D objects from digital models. However, this process releases volatile organic compounds, ultrafine p

Career Path: Pharmaceutical Consultant in the Field of Occupational, Environmental, and Quality Toxicology

Aug 16 2024 27 mins  
This podcast is part of a series on different career paths in the field of toxicology. In this episode, Dr. Chuck Schwartz, PhD, DABT, shares the career path that led to his current position as the principal consulting toxicologist and managing member of a consulting practice that specializes in the fields of occupational and quality toxicology. Dr. Schwartz's experiences as a corp

Discussions on Identifying Seizures Liability in Nonclinical Studies

Jul 01 2024 25 mins  
Drug-induced seizures are a major concern for central nervous system active pharmaceuticals during development. Currently, there are no guidelines for interrogating and mitigating seizure liability associated with new pharmaceuticals. Because of the risks to patient safety during clinical trials, the understanding of nonclinical characterization that informs the translation of risk

Alternative and Nontraditional Species Series: The Use of Transgenic and Disease Mouse Animal Models for Toxicology Studies

May 06 2024 28 mins  
In this ToxChats© podcast, we spoke with Dr. René Meisner, Head of Safety Assessment at Denali Therapeutics, on using both transgenic and disease mouse models in a drug development program. Topics include considerations for program design, regulatory interactions, and the role of these mice moving forward. s for program design, regulatory interactions, and the role of these mice

Identifying an Appropriate Sponsor to Support Your Growth and Success in the Workplace

Mar 04 2024 18 mins  
Mentors meet with you, listen to you, and provide advice. Sponsors have influence, connections, and can speak to your talents, abilities, and potential in new opportunities. Learning how to distinguish between the two and identify a sponsor that can help support your key growth and access to future opportunities is a critical skill needed to support one's professional and personal

Alternative and Nontraditional Species Series: Fertilized Egg Model as an Alternative Species for Safety Assessment Studies

Jan 29 2024 20 mins  
In this podcast, Dr. Tetyana Cheairs gives a detailed overview of the fertilized egg model and how it is currently being used in safety assessment studies. She then describes important ways in which toxicologists and drug development programs could benefit from utilizing the fertilized egg model. This podcast is incredibly informative and is tailored to be understood and enjoyed by

Alternative and Nontraditional Species Series: Advantages and Challenges of Using Rabbits

Jan 22 2024 26 mins  
In this ToxChats© podcast, Dr. Elise Lewis provides a thorough background on the use of rabbits in DART and the future direction of their use as alternative species for other types of nonclinical safety studies. Topics include advantages and challenges, sourcing, behavior, physiology, and the practicality of rabbits, and the translatability of rabbit data to other nonclinical spec