Two Scientists Walk Into a Bar

Nov 16 2024 44 ep. 29 mins 33.6k
Two Scientists Walk Into a Bar Podcast artwork

From research on cancer vaccines to why we feel pain, scientists are tackling some of the biggest challenges in human biology. Want to find out what they’re working on? Pull up a stool for "Two Scientists Walk Into a Bar." Subscribe below to catch each episode as it goes live.

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S5E09: AI and The Future of Medicine

Nov 16 2024 40 mins  
Machine learning and generative AI are transforming the ways we live and work, but how do these tools fit into the landscape of drug discovery? In our season 5 finale, co-host Danielle Mandikian is joined by Rich Bonneau, Vice President of Machine Learning, Drug Discovery, to break down the fast-paced, expansive – and sometimes perplexing – world of AI and biology. Together, th

S5E08: A Deep Dive into Drug Modalities

Oct 30 2024 31 mins  
Small molecules, antibodies, gene therapies – there are so many types of medicines scientists can consider when developing a new treatment for a disease. In this episode, Karin Briner, Senior Vice President and Head of Drug Discovery, joins co-host Maria Wilson to break down different therapeutic modalities, or types of treatments. Together, they cover a wide range of modalities

S5E07: Organoids: From Dish to Discovery

Sep 25 2024 39 mins  
Did you know that scientists can grow three-dimensional, miniature versions of human organs in a dish? These tiny in vitro models, known as organoids, are helping scientists to better understand human disease and to test new treatments. In this episode, co-host Danielle Mandikian sits down with Kim Homan, Senior Director and Distinguished Scientist, Complex in vitro Systems Lab, to

S5E06: Cancer Conversations: Early Detection and Potent Solutions

Aug 27 2024 29 mins  
To defeat cancer, we need to understand it better. How does it grow? How do we detect it early? And most importantly, how do we treat it? In this episode, co-host Maria Wilson chats with oncology expert Louis Vermeulen, VP and Senior Fellow, Discovery Oncology, about what’s new and exciting in cancer research. Together, they explore the importance of early detection, explain conc

S5E05: The Streets and Deets of Obesity

Jul 31 2024 38 mins  
What drives metabolic conditions like obesity? In this special episode, co-host and cardiovascular disease expert Maria Wilson, gRED Executive Director and Cardiovascular and Metabolism Research Head, takes the hot seat with fellow host Danielle Mandikian, gRED Senior Principal Scientist, to discuss the complex world of obesity. Tune in to hear about the biological and environmenta

S5E04: Engineering Therapeutic Antibodies

Jun 26 2024 29 mins  
Antibodies are proteins produced by our immune system that neutralize or help destroy abnormal cells and foreign agents, like bacteria and viruses. However, their utility extends beyond our bodies’ defense system. Antibodies can also be engineered in the lab to be used as therapies. Today, over 170 antibodies have been approved as medicines to treat a wide range of diseases inclu

S5E03: No Delivery, No Drug

May 29 2024 35 mins  
Many health conditions require medicines that can be delivered to specific parts of the body. For instance, someone with asthma requires medication that targets the lungs, while someone with a neurodegenerative disease needs therapeutics that can penetrate the blood-brain barrier. But how do scientists create medicines that not only reach their intended targets but also produce the

S5E02: Seeing Clearly: The Past, Present and Future of Eye Treatment

Apr 30 2024 36 mins  
Imagine the eyes as cameras, where the cornea acts as the lens and the retina as the film. As with a camera, if something goes wrong in the eye, it needs to be fixed to address the specific problem and restore function. While some visual impairments can be corrected with glasses or surgery, some conditions require medicines – like those that slow or stop blood vessel growth in th

S5E01: Merging Minds and Machines: The Future of Drug Discovery

Mar 25 2024 36 mins  
Computational approaches have revolutionized how we interpret data. With the advent of genomic sequencing, scientists can derive significant conclusions from sequence data. For example, through transcriptomics – the study of genes and their expression in different cells – researchers have made groundbreaking discoveries in fields like developmental and disease biology. More rec

Season Five Teaser

Feb 07 2024 4 mins  
Join Danielle Mandikian and Maria Wilson as they kick off season five of Two Scientists Walk Into a Bar. Hear about their recent lab adventures and enjoy a sneak preview of exciting topics for our new season. From demystifying the impact of AI and machine learning in drug development to exploring diverse modalities for treating diseases, we've got an exciting lineup in store. Subsc