Jul 23 2022 18 mins 5
In this episode of Root of the Cause Radio, I’ll be covering the good, the bad and the ugly of estrogen metabolites: the more benign 2-Hydroxyestrone, the duality of the 16-Hydroxyestrone and the dreaded 4-Hydroxyestrone.
1:53 - Phase 1 estrogen detoxification and estrogen metabolites
2:47 - 16-Hydroxyestrone, the impact, risk and reasons for high levels and the possible downsides of very low levels
4:06 - Can Estriol convert into anything harmful or helpful?
5:40 - The bad and ugly of the 4-Hydroxyestrone and how methylation plays a critical role
7:42 - Phosphatidylcholine and how it can indirectly help to neutralize the 4-Hydroxyestrone metabolite
9:23 - What happens to the 4-Hydroxyestrones that don’t get methylated? Hint: DNA damage
9:42 - How sulforaphane stimulates glutathione S transferase and quinone reductase to mop up DNA damaging quinones
11:12 - Can you measure quinone levels? Can you measure DNA damage from oxidative stress (8-hydroxy-2-deoxyguanosine)?
12:00 - How glutathione is made and the critical nutrients necessary
13:49 - How glutathione and sulforaphane impact estrogen metabolites that don’t get methylated
