Oct 28 2024 20 mins
Our host discusses with Drs. Shaomin Hu from Cleveland Clinic and Yue Xue MD PhD, from Case Western
Reserve in Cleveland Ohio, their multi-institutional study on gastrointestinal (GI) tract involvement by Langerhans
cell histiocytosis (LCH). The authors highlight new insights from their large study showing that adult patients with
multisystem LCH exhibit similar clinicopathologic features to those of pediatric patients. Adults with single-system
LCH involving the GI tract have an excellent prognosis, whereas multisystem LCH occurring at any age carries an
unfavorable prognosis. High-risk features of GI LCH include pediatric age, GI symptomatology, noncolorectal GI
involvement, multifocal GI disease, nonpolypoid lesions, and infiltrative growth pattern.