ModPath Chat

Dec 06 2024 92 ep. 20 mins 35
ModPath Chat Podcast artwork

ModPath Chat is the official podcast of Modern Pathology, the journal of the US and Canadian Academy of Pathology (USCAP). ModPath Chat features interviews with authors, opinion leaders and experts on the latest science, technology, and developments in the field of pathology. The monthly podcast series is hosted by Dr. George J. Netto, the Editor-in-Chief of Modern Pathology and the Simon Flexner Professor and Chair, Department of Pathology and Laboratory Medicine at the University of Pennsylvania Perelman School of Medicine in Philadelphia

  Health & Fitness  Science
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Fumarate hydratase deficient renal cell carcinoma. Guido Martignoni and Anna Caliò

Dec 06 2024 18 mins  
Drs. Guido Martignoni and Anna Caliò from the University of Verona in Italy discuss their recent study on primary and metastatic fumarate hydratase (FH)-deficient renal cell carcinomas. Six metastatic tumors were histologically documented with high frequency of involvement of lymph nodes, liver and peritoneal cavity. Metastases were morphologically heterogeneous often differing fr

Intraductal oncocytic papillary neoplasm, Claudio Luchini and Gaetano Paolini

Nov 18 2024 22 mins  
Dr. Claudio Luchini from the University of Verona and Dr. Gaetano Paolini from Brescia University Hospital in Italy discuss their systematic review article, published in Modern Pathology, on Intraductal oncocytic papillary neoplasm (IOPN) of the pancreas.

Gastrointestinal Langerhans cell histiocytosis: New insights. Shaomin Hu and Yue Xue

Oct 28 2024 20 mins  
Our host discusses with Drs. Shaomin Hu from Cleveland Clinic and Yue Xue MD PhD, from Case Western Reserve in Cleveland Ohio, their multi-institutional study on gastrointestinal (GI) tract involvement by Langerhans cell histiocytosis (LCH). The authors highlight new insights from their large study showing that adult patients with multisystem LCH exhibit similar clinicopathol

Opening the Black Box: Spatial Transcriptomics and the Relevance of Artificial Intelligence–Detected Prognostic Regions in High-Grade Serous Carcinoma. Anna Ray Laury et al

Oct 10 2024 19 mins  
Our host discusses with Dr. Anna Laury, from the Department of Pathology, University of Helsinki, Finland, her team's study on the utilization of AI-guided spatial transcriptomic analysis to allow for the biological interpretation of morphologic features detected by AI algorithms when applied to WSI of standard H&E sections. The authors previously trained an AI model to identif

Pathologist-Driven Reflex Somatic Tumor DDR Testing in Localized Prostate Cancer. Susan Prendeville and Shamini Selvarajah

Sep 09 2024 19 mins  
Our host discusses with Drs. Prendeville and Selvarajah, from the departments of Laboratory Medicine and Pathobiology at the University of Toronto, their recent study on Pathologist-Driven somatic testing for DNA Damage Repair (DDR) in prostate carcinoma (PCa). 516 FFPE samples from metastatic and localized high risk PCa cases including needle biopsies, TURP and RP specimens were t

Staging of Multiple NSCLC: Paradigm shift using molecular methods Natasha Rekhtman

Aug 21 2024 29 mins  
Non-small cell lung carcinomas (NSCLCs) commonly present as 2 or more separate tumors. They encompass separate primary lung carcinomas (SPLCs), representing independently arising tumors, or intrapulmonary metastases (IPMs), representing intrapulmonary spread of a single tumor. In this episode, Dr. Natasha Rekhtman, from Memorial Sloan Kettering Cancer Ctr, NY provides an update on

A Portrait of HER2- Low Invasive Lobular Carcinoma (ILC) of Breast. Lounes Djerroudi Anne Vincent-Salomon

Aug 02 2024 16 mins  
Our host discusses with Drs. Djerroudi and Vincent-Salomon, from the Institut Curie in Paris France, their recent study comparing HER2-negative invasive breast cancer of no special type (IBC-NST), with HER2-negative ILC. HER2-negative ILC had a higher frequency of HER2-zero cases (59.4% vs 53.7%) and a lower frequency of HER2-low (40.6% vs 46.3%). Clinicopathological features asso

Special Episode - Meet the Listeners

Jun 14 2024 22 mins  
A most exciting conversation with some of the many engaged listeners of our podcast around the globe. Our host is joined by Dr. Zeeshan Ansar from Karachi, Pakistan; Dr. Emilian Olteanu, from Timisoara, Romania; Dr. Sanam Loghavi from Houston, USA and Dr. Sanjay Mukhopadhyay, from Clevland, USA.

Molecular Profiling of Sinonasal Olfactory Carcinoma with Lisa Rooper, MD

May 31 2024 19 mins  
In this episode, our host and Dr. Lisa Rooper from Johns Hopkins University, on behalf of her group of esteemed coauthors, discuss their recent study on the molecular characteristics of “Olfactory Carcinoma.” Targeted molecular profiling of 23 cases of the rare sinonasal tumor was performed to help clarify their pathogenesis and classification. The authors found recurrent Wnt p

Liver Pathology in the Molecular Era: A Conversation with the USCAP 2024 Long Course Codirectors

May 22 2024 19 mins  
Integration of molecular analyses in routine diagnostics is the new practice paradigm of surgical pathology practice. The 2024 USCAP Long Course led by Dr. John Hart from the University of Chicago and Daniela Allende of Cleveland Clinic focuses on hepatic neoplasms and medical diseases where there are opportunities for ancillary molecular testing to refine the diagnosis and provide