Channel Your Enthusiasm

Aug 16 2024 21 ep. 94 mins 68
Channel Your Enthusiasm Podcast artwork

A chapter by chapter recap of Burton Rose’s classic, The Clinical Physiology of Acid Base and Electrolyte Disorders, a kidney physiology book for nephrologists, fellows, residents and medical students.

  Health & Fitness  Education  Science
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Chapter Fifteen, part 2: Clinical Use of Diuretics

Aug 16 2024 96 mins  
ReferencesProximal Tubule-Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice Melanie is in love with this paper that shows that sodium retention Bumetanide and furosemide in heart failure everyone agreed that we love this classic paper from Craig Brater on diuretics (and the source of figure 15-6).&n

Chapter Fifteen, part 1: Clinical Use of Diuretics

May 13 2024 120 mins  
Outline Chapter 15 — Clinical Use of Diuretics- Among most commonly used drugs- Block NaCl reabsorption at different sites along the nephron- The ability to induce negative balance has made them useful in multiple diseases- Edematous states- Hypertension- Mechanism of action- Three major classes- Loop- NaK2Cl- Up to 25% of filtered sodium excreted- Thiazide- NCC- Up to 3-5% of fi

Chapter Fourteen, part 2. Hypovolemic States

Mar 24 2024 99 mins  
Outline Chapter 14 — Treatment- Treatment - Both oral and IV treatment can be used for volume replacement - The goal of therapy are to restore normovolemia - And to correct associated acid-base and electrolyte disorders - Oral Therapy - Usually can be accomplished with increased water and dietary sodium - May use salt tablets - Glucose often added to resuscitation fluids - Provid

Chapter Fourteen, part 1. Hypovolemic States

Jan 28 2024 105 mins  
OutlineChapter 14- Hypovolemic States- Etiology - True volume depletion occurs when fluid is lost from from the extracellular fluid at a rate exceeding intake - Can come the GI tract - Lungs - Urine - Sequestration in the body in a “third space” that is not in equilibrium with the extracellular fluid. - When losses occur two responses ameliorate them - Our intake of Na and flui

Chapter Thirteen Meaning and Application of Urine Chemistries

Sep 17 2023 91 mins  
ReferencesJC mentioned that the diagnostic accuracy of 24 hour urine collection increases with more collections! Metabolic evaluation of patients with recurrent idiopathic calcium nephrolithiasisWe didn't refer to a particular study on sodium intake and the 24 hour urine but this meta-analysis Comparison of 24‐hour urine and 24‐hour diet recall for estimating dietary sodium int

Chapter Eleven, part 2: Regulation of Acid-Base Balance

May 20 2023 90 mins  
ReferencesWe considered the complexity of the machinery to excrete ammonium in the context of research on dietary protein and how high protein intake may increase glomerular pressure and contribute to progressive renal disease (many refer to this as the “Brenner hypothesis”). Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediat

The 2023 NKF Clinical Meeting Live Recording: Diuretic Draft

Apr 14 2023 111 mins  
The Channelers went where no nephrology podcasters have gone before, recording in front of a live audience at the National Kidney Foundation Clinical Meeting in Austin. We had all eight Channelers doing a live podcast.We did a Freely Filtered-inspired draft of the best diuretics.The draft order:Leticia Rolon Anna Gaddy Joel TopfRoger Rodby Josh Waitzman Amy Yau JC Velez And Melanie

A Very Special Episode: Meet the Glaucomfleckens

Mar 04 2023 56 mins  

Chapter Eleven, part 1: Regulation of Acid-Base Balance

Feb 12 2023 97 mins  
ReferencesWe considered the effect of a high protein diet and potential metabolic acidosis on kidney function. This review is of interest by Donald Wesson, a champion for addressing this issue and limiting animal protein: Mechanisms of Metabolic Acidosis-Induced Kidney Injury in Chronic Kidney DiseaseHostetter explored the effect of a high protein diet in the remnant kidney model w

Chapter Ten : Acid-Base Physiology

Dec 31 2022 78 mins  
References for Chapter 10We did not mention many references in our discussion today but our listeners may enjoy some of the references below. Effects of pH on Potassium: New Explanations for Old Observations - PMC although the focus of this article is on potassium, this elegant review by Aronson and Giebisch reviews intracellular shifts as it relates to pH and K+.Josh swooned