Ground Truths

Nov 30 2024 49 ep. 43 mins 161
Ground Truths Podcast artwork

Facts, data, and analytics about biomedical matters.

erictopol.substack.com

  Science  Health & Fitness
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Kevin Hall: What Should We Eat?

Nov 30 2024 47 mins  
A leader for conducting rigorous randomized trials of humans along with animal models for understanding nutrition and metabolism, Dr. Kevin Hall is a Senior Investigator at the National Institutes of Health, and Section Chief of the Integrative Physiology Section, NIDDK. In this podcast, we reviewed his prolific body of research a recent publications. The timing of optimizing our d

The Glaucomfleckens: The Best in Medical Comedy

Nov 16 2024 35 mins  
Below is a brief video snippet from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The current one is here. If you like the YouTube format, please subscribe! This one has embedded one of my favorite TikTok’s from Will. There are several links to others in the transcript. The audios are also available on Apple and Spotify.Transcript with l

Rachael Bedard: A Geriatric Physician and Champion for Patients Without a Voice

Nov 02 2024 43 mins  
Above is a brief video snippet from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are also available on Apple and Spotify.Transcript with links to audio and external citationsEric Topol (00:06):Well, hello it's Eric Topol with Ground Truths, and I'm really delighted to welcome Dr. Rachael Bedard, who is a physician geriatrician

Katerina Akassoglou: Blood Clots, Brain Inflammation, and Covid

Oct 19 2024 35 mins  
Superimposed on an impressive body of work on the blood-brain-barrier and immune system, Prof Akassoglou and her collaborators just published an elegant study in Nature that centered on the direct binding os the SARS-CoV-2 spike protein to fibrin with marked downstream pro-inflammatory effects. The findings and potential treatments have implications beyond Covid, Long Covid to othe

Patrick Hsu: A Trailblazer in Digital Biology

Oct 13 2024 47 mins  
When I think of digital biology, I think of Patrick Hsu—he’s the prototype, a rarified talent in both life and computer science, who recently led the team that discovered bridge RNAs, what may be considered CRISPR 3.0 for genome editing, and is building new generative A.I. models for life science. You might call them LLLMs-large language of life models. He is Co-Founder and a C

AI Snake Oil—A New Book by 2 Princeton University Computer Scientists

Sep 23 2024 39 mins  
Arvind Narayanan and Sayash Kapoor are well regarded computer scientists at Princeton University and have just published a book with a provocative title, AI Snake Oil. Here I’ve interviewed Sayash and challenged him on this dismal title, for which he provides solid examples of predictive AI’s failures. Then we get into the promise of generative AI.Full videos of all Ground Trut

Francis Collins: On Truth, Science, Faith and Trust

Sep 11 2024 40 mins  
Francis Collins is a veritable national treasure. He directed the National Institutes of Health from 2009 to 2021. Prior to that he led the National Human Genetics Research Institute (NHGRI) from 1997-2009, during which the human genome was first sequenced. As a physician-scientist, he has made multiple seminal discoveries on the genetic underpinnings of cystic fibrosis, Huntington

Joseph Allen: The Pivotal Importance of Air Quality, Ventilation and Exposures (Such as "Forever Chemicals") For Our Health

Sep 05 2024 61 mins  
Professor Joseph Allen directs the Healthy Buildings Program at Harvard Chan School of Public Health. His expertise extends far beyond what makes buildings healthy. He has been a leading voice and advocate during the Covid pandemic for air quality and ventilation. He coined the term “Forever Chemicals” and has written extensively on this vital topic, no less other important exp

Steve Horvath: Our Epigenetic Age Clocks

Aug 23 2024 41 mins  
Steve Horvath made the seminal discovery of the—Horvath Clock— an epigenetic clock based on DNA methylation, which is now being used extensively in medical research and offered commercially for individuals (←we talk about that!). He was on the faculty at UCLA from 2000-2022 as a Professor of Human Genetics and Biostatistics, and now works on anti-aging research at Altos Labs.

Pradeep Natarajan: Preventing Heart Disease

Aug 13 2024 57 mins  
Pradeep is a brilliant geneticist and Director of Preventive Cardiology, holds the Paul & Phyllis Fireman Endowed Chair in Vascular Medicine at Mass General Hospital and on faculty at Harvard Medical School and the Broad Institute. His prolific research has been illuminating for the field of improving our approach to reduce the risk of heart disease. That’s especially important b