The Parkinson’s Research Podcast: New Discoveries in Neuroscience

Oct 15 2024 26 ep. 43 mins 10
The Parkinson’s Research Podcast: New Discoveries in Neuroscience artwork

In this podcast, The Michael J. Fox Foundation for Parkinson’s Research brings you right to the cutting edge of neuroscience to discuss the latest discoveries in the field of neuroscience, with a focus on Parkinson’s disease (PD). We are working at the forefront of PD research to accelerate scientific breakthroughs by providing funding opportunities, tools and resources to develop new treatments, find cures and improve quality of life for people living with Parkinson’s disease. If you’re a scientist, clinician or industry professional interested in gaining in-depth insights into the latest advances in basic science, translational research and clinical trials for new therapies and therapeutics, this show is for you. Our host Dr. Marie McNeely interviews experts on topics such as the impacts of genetics, mechanisms of neurodegeneration, neuroimaging, biomarkers, diagnostics, applications of machine learning and artificial intelligence, drug development, novel treatment technologies and more. Subscribe to stay up to date on key developments in neuroscience, neurology, neurodegeneration and Parkinson’s disease research.

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25: Creating Alpha-Synuclein Cell Lines and Supporting Open Science with Birgitt Schüle

Oct 15 2024 36 mins  
Stem cell models derived from patients with Parkinson’s disease are valuable tools that are helping researchers around the world to better understand the underlying causes of neurodegeneration and to develop biomarkers and new therapies. To maximize the potential impacts of these tools, it is critical that they are developed and shared according to the principles of open science.

24: Developing FLEXISyn to Identify and Measure Changes in Alpha-Synuclein in Parkinson's Disease with Judith Steen

Oct 01 2024 35 mins  
New qualitative and quantitative tools are being developed to measure and track changes in proteins relevant for neurodegenerative disease, and these tools have the potential to accelerate drug discovery and clinical trials. In this episode, Dr. Judith Steen discusses her work creating novel qualitative and quantitative tools and workflows at the interface of proteomics and transcr

23: Clinical Applications of Biomarkers and Large-Scale Collaborative Research with Charles Adler

Sep 17 2024 45 mins  
Substantial research has focused on identifying biomarkers for the diagnosis of Parkinson's disease (PD) as well as monitoring progression of the disease. In developing these biomarkers, it is critical for scientists to consider how the biomarkers will ultimately be used in the clinic and in clinical trials research. In this interview, Dr. Charles (Chuck) Adler shares his perspecti

22: Investigating Light Therapy For Sleep and Motor Function in People with PD with Beatrix Feigl

Sep 03 2024 41 mins  
Sleep disturbances, such as insomnia, sleep fragmentation, excessive daytime sleepiness, and REM sleep behavior disorder are common in people with Parkinson's disease (PD). Poor sleep quality can also impact other domains of function, including motor function. Prior research has shown that a type of photoreceptor cell in the retina, called melanopsin cells, provide the main light s

21: The Autophagy-Lysosomal Pathway and Development of Relevant PD Biomarkers with Zhenyu Yue

Aug 20 2024 31 mins  
Though existing evidence supports that dysfunction in the clearing of cellular debris plays an important role in the development of Parkinson's disease, many unanswered questions remain regarding the mechanisms of the autophagy-lysosomal pathway involved in this process. In particular, research in the field has been limited by a lack of reliable, quantitative tests for mo

20: Studying CSF Element Profiles and Tear Fluid as Potential Biomarkers, and Novel and Combined Therapies for PD with Paul Lingor

Aug 06 2024 47 mins  
Evidence supports that dysfunction in the homeostasis of iron and other elements likely contributes to the pathophysiological mechanisms of Parkinson's disease, but we have yet to develop suitable elemental biomarkers for use in diagnosing and monitoring the progression of Parkinson's disease. Dr. Paul Lingor discusses his work in this area to identify patterns of bioelements

19: Current and Emerging Imaging Biomarkers for Diagnosis and Prognosis of PD and Atypical Parkinsonism with Antonio Strafella

Jul 23 2024 37 mins  
Identifying reliable biomarkers for the diagnosis and prognosis of Parkinson's disease and atypical parkinsonism would have substantial impacts on clinical trials and clinical practice. A particularly active area of research is the development of novel molecular imaging biomarkers that can be used in combination with common neuroimaging approaches. Dr. Antonio Strafe

18: Examining Links Between Environmental Exposure, Poor Olfaction, and Parkinson's Disease with Honglei Chen

Jul 09 2024 46 mins  
Prior studies have established links between poor olfaction and Parkinson's disease, and impaired sense of smell is a common prodromal symptom of Parkinson's disease. The causes and mechanisms of prodromal neurodegeneration are actively being researched. However, environmental exposure to pesticides or other chemicals may trigger or modify the course of neurodegeneration, potential

17: Developing Interventions to Improve Gait and Increase Physical Activity in Parkinson’s Disease with Gammon Earhart

Jun 18 2024 42 mins  
Gait impairments such as slow speed, small steps, and high variability from step to step are common in people with Parkinson's disease, and these changes begin to occur early in the course of disease. Freezing of gait may develop later for some individuals, and it has been linked to falls and other adverse outcomes. When the quality of walking declines, it can lead to a reduction&n

16: Studying Basal Ganglia Circuits and Developing Deep Brain Stimulation Protocols for Longer-Lasting Effects with Aryn Gittis

Jun 04 2024 44 mins  
Improving our understanding of the complex neural circuits involved in normal function of the basal ganglia and other parts of the brain impacted by Parkinson's disease is critical for developing more targeted and more effective treatment approaches. In this episode, Dr. Aryn Gittis discusses her research examining how the activity of specific basal ganglia circuits relat