American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

Feb 21 2025 42 ep. 13 mins 6
American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast artwork

Podcasts of the American Journal of Physiology-Gastrointestinal and Liver Physiology

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"Got Guts" The Micro Version: Pacing Inhibits Slow Wave Dysrhythmias in the Intestine

Feb 21 2025 7 mins  
In this podcast coauthors Nipuni D. Nagahawatte and Leo K. Cheng discuss their research titled "High-energy pacing inhibits slow-wave dysrhythmias in the small intestine." Glucagon was infused in pigs to induce hyperglycemia and the resulting slow-wave response in the intact jejunum was defined in high resolution for the first time. Subsequently, with pacing, the glucagon-induced d

"Got Guts" Special Episode: The GI and Liver Section at the 2025 American Physiology Summit

Jan 23 2025 20 mins  
In this episode, AJP GI and Liver Physiology's Editor-in-Chief Mark Frey and Nicholas Zachos representative of the Gastrointestinal and Liver Physiology Section provide an exclusive preview of the GI programming at the upcoming APS Summit. They walk listeners through the exciting lineup of sessions, symposia, and featured topics designed to ignite new insights and collaborations wi

"Got Guts" The Micro Version: Electromechanical Coupling of the In-Vivo Pylorus

Nov 01 2024 13 mins  
Join coauthors Sam Simmonds, Ashton Matthee, and Timothy R. Angeli-Gordon as they delve into their recently published research, "Electromechanical Coupling and Anatomy of the In Vivo Gastroduodenal Junction." In this episode, they explore cutting-edge techniques like electrical mapping, impedance planimetry, and histological analysis to investigate the complex dynamics of the gastr

"Got Guts" The Micro Version: Effect of amniotic fluid on the esophageal epithelium

Oct 15 2024 7 mins  
Join coauthors Mark Rochman and Marc E. Rothenberg as they explore their recently published paper, "Amniotic Fluid Modifies Esophageal Epithelium Differentiation and Inflammatory Responses." In this engaging episode, they discuss how the interaction between amniotic fluid and the esophageal epithelium during pregnancy impacts epithelial differentiation and influences the tissue's r

"Got Guts" The Micro Version: The Effects of Simulated Gastroesophageal Reflux on Infant Pig Oropharyngeal Feeding Physiology

Oct 14 2024 7 mins  
Join coauthor Chloe Edmonds in this insightful episode as she delves into her recently published paper, "The Effects of Simulated Gastroesophageal Reflux on Infant Pig Oropharyngeal Feeding Physiology." Chloe explores how simulating gastroesophageal reflux in an infant pig model reveals significant alterations in pharyngeal swallowing dynamics. Discover how the integration of esoph

"Got Guts" The Micro Version: Autoimmune liver disease and hormonal responses

Sep 27 2024 5 mins  
In this episode, coauthors Anne-Sofie H. Jensen and Nicolai J. Wewer Albrechtsen discuss the recently published research titled "Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease." The authors reveal that patients with autoimmune liver disease, even in the absence of overt diabetes, experience early glucose dis

"Got Guts" The Micro Version: Inhibitory neurotransmission in the internal anal sphincter

Sep 06 2024 8 mins  
Coauthor Caroline A. Cobine dives into the fascinating world of internal anal sphincter biology in the latest episode of "Gut Guts." The research uncovers direct and indirect neural pathways that modulate intracellular calcium activity in interstitial cells of Cajal, shedding light on their role in smooth muscle cell function. Article Citation: Modulation of intracellular calcium

"Got Guts" The Micro Version: Mechanical Stress-induced Connective Tissue Growth Factor and Intestinal Fibrosis

Aug 23 2024 8 mins  
In this episode of "Gut Guts" coauthor Xuan-Zheng Shi discusses new research on intestinal fibrosis in Crohn’s-like colitis. The study found that mechanical stress causes a protein called CTGF to increase, leading to fibrosis. In a rat model, easing the mechanical stress reduced connective tissue growth factor (CTGF) and lessened fibrosis. This suggests that mechanical stress may

"Got Guts" The Micro Version: Characterization of Rat Gastric Slow Wave Activity

Aug 14 2024 8 mins  
Tune in to our latest podcast episode where Peng Du, Omkar N. Athavale, and Madeleine R. Di Natale dive into the fascinating world of gastric slow-wave conduction. They discuss their recent article titled "Mapping the rat gastric slow-wave conduction pathway: bridging in vitro and in vivo methods, revealing a loosely coupled region in the distal stomach" revealing regional variatio

"Got Guts" The Micro Version: Implicating the Cholecystokinin B Receptor in Liver Stem Cell Oncogenesis

Jun 21 2024 4 mins  
In this episode of "Got Guts" The Micro Version, Jill P. Smith highlights the recently published research titled "Implicating the cholecystokinin B receptor in liver stem cell oncogenesis." This investigation identified a novel pathway involving the activation of hepatic stem cells and liver oncogenesis. Receptor blockade or genetic disruption of the cholecystokinin-B receptor (CCK