Nick Sterling, MD, PhD

Jan 15 2025 15 ep. 28 mins 2
Nick Sterling, MD, PhD Podcast artwork

Physician focused on the science of preventative health, aging, and athletic performance.

  Health & Fitness
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Ozempic in the ER: Side Effects of GLP-1 Receptor Agonists

Jan 15 2025 6 mins  
What are some common side effects of medications like Ozempic and Wegovy? From the front lines of healthcare, we explore adverse effects of these medications based on real-world visits to the emergency department. Learn about common side effects such as nausea, dehydration, and muscle wasting, as well as lesser-known risks like starvation ketosis and mood changes. Chapters 0:00 -

Ketamine for Depression, Anxiety, & PTSD - Changing the Brain Through Neuroplasticity

Dec 19 2024 15 mins  
In this episode, we explore how ketamine, a dissociative anesthetic with a long history in medical use, is now being investigated for its rapid and sustained effects on depression, anxiety, and PTSD. We discuss its role in promoting neuroplasticity—rewiring the brain's structure to counteract stress-induced atrophy—and review the evidence from clinical trials, including a landm

What are the Most Important Decades for Aging?

Nov 22 2024 6 mins  
In this episode, we talk about a recent study from Nature Aging that suggests aging may not progress in a straight line. Using data from thousands of biological measurements, researchers identified key ages—44 and 60—where changes in aging appear to accelerate. We review what this means for our understanding of aging, how it affects multiple systems in the body, and the potenti

Can we Slow the Speed of Aging? Biological Age & Epigenetics - Varun Dwaraka, PhD

Aug 29 2024 83 mins  
Can we slow the speed of aging? In this episode, Dr. Varun Dwaraka, Head of Bioinformatics at TruDiagnostic, walks us through through the science of measuring "biological age" using epigenetic markers, such as DNA methylation. We discuss how epigenetics (i.e. DNA methylation), may provide biomarkers of biological age, the rate at which aging occurs, and potentially early

Preventing Atherosclerosis & Heart Disease (ApoB, Cholesterol, and Lipids) | Tom Dayspring, MD

Jul 15 2024 76 mins  
Why do humans get cardiovascular disease and how can we prevent it? These are critical processes to understand for anyone who is interested in living a longer and healthier life. I'm very honored to talk with Dr. Tom Dayspring, a world-renowned clinical lipidologist and physician whose topic expertise is unparalleled. We discuss the underlying process of atherosclerosis & t

Metabolic Health, Insulin Resistance, & Mitochondrial Health | Nicolas Verhoeven (Physionic)

Apr 15 2024 68 mins  
In this episode, I had the pleasure of sitting down with Nicolas Verhoeven of Physionic. We focus our attention on metabolic health and, specifically, the energy-related, cellular, and nutritional mechanisms of insulin resistance. Nicolas reviews evidence pertaining to the reversal of insulin resistance and dietary clinical trials demonstrating remission of type 2 diabetes. Nicolas

How I Went from 5K to Ironman Triathlons & Ultra-Marathons. Building Speed & Endurance

Mar 13 2024 13 mins  
In this episode, we discuss polarized training, which includes high-volume low intensity training and high-intensity training. We review the scientific literature pertaining to endurance performance, mechanisms of recovery debt, adaptations to various exercise modalities, and developing training programs around polarized training. MAF-180: https://philmaffetone.com/180-formula/ #ul

Muscle Loss & "Ozempic" - Prevention & What We Know | Nick Sterling, MD, PhD #8 | Nick Sterling, MD, PhD #8

Nov 21 2023 8 mins  
Does muscle loss occur in people taking GLP-1 receptor agonists such as semaglutide (marketed as "Ozempic" and "Wegovy") or combined GLP-1/GIP agonists like tirzepatide (marketed as "Mounjaro")? In this episode, we discuss current evidence regarding these next-generation weight loss drugs and muscle wasting, as well as principles of preventing muscle l

How “Ozempic” Works – Weight Loss, Weight Regain, & Neuroscience | Nick Sterling, MD, PhD #7

Jul 29 2023 11 mins  
How do drugs like Ozempic (semaglutide) cause weight loss? In this episode, we discuss how these drugs (GLP-1 receptor agonists) target specific areas in the brain to suppress appetite and facilitate weight loss. We also discuss clinical trials data suggesting that these drugs and/or the weight loss that they facilitate may have cardioprotective effects. Lastly, we will also examin

How Fats & Carbs Drive Food Intake | Nick Sterling, MD, PhD #6

Jul 29 2023 5 mins  
Highly processed foods have been shown to lead to weight gain and are thought to drive intake through several mechanisms. Recent research suggests that the effect of combining fats and carbs on appetite might be more than the sum of their individual effects. Highly processed foods, accordingly, might simulate increased intake via the ratio of macronutrients. Link to episode on ne