Nick Sterling, MD, PhD

Nov 22 2024 13 ep. 31 mins 1
Nick Sterling, MD, PhD Podcast artwork

Physician focused on the science of metabolic health, aging, longevity, and athletic performance.

  Health & Fitness
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What are the Most Important Decades for Aging?

Nov 22 2024 6 mins  
In this episode, we talk about a recent study from Nature Aging that suggests aging may not progress in a straight line. Using data from thousands of biological measurements, researchers identified key ages—44 and 60—where changes in aging appear to accelerate. We review what this means for our understanding of aging, how it affects multiple systems in the body, and the potenti

Can we Slow the Speed of Aging? Biological Age & Epigenetics - Varun Dwaraka, PhD

Aug 29 2024 83 mins  
Can we slow the speed of aging? In this episode, Dr. Varun Dwaraka, Head of Bioinformatics at TruDiagnostic, walks us through through the science of measuring "biological age" using epigenetic markers, such as DNA methylation. We discuss how epigenetics (i.e. DNA methylation), may provide biomarkers of biological age, the rate at which aging occurs, and potentially early

Preventing Atherosclerosis & Heart Disease (ApoB, Cholesterol, and Lipids) | Tom Dayspring, MD

Jul 15 2024 76 mins  
Why do humans get cardiovascular disease and how can we prevent it? These are critical processes to understand for anyone who is interested in living a longer and healthier life. I'm very honored to talk with Dr. Tom Dayspring, a world-renowned clinical lipidologist and physician whose topic expertise is unparalleled. We discuss the underlying process of atherosclerosis & t

Metabolic Health, Insulin Resistance, & Mitochondrial Health | Nicolas Verhoeven (Physionic)

Apr 15 2024 68 mins  
In this episode, I had the pleasure of sitting down with Nicolas Verhoeven of Physionic. We focus our attention on metabolic health and, specifically, the energy-related, cellular, and nutritional mechanisms of insulin resistance. Nicolas reviews evidence pertaining to the reversal of insulin resistance and dietary clinical trials demonstrating remission of type 2 diabetes. Nicolas

How I Went from 5K to Ironman Triathlons & Ultra-Marathons. Building Speed & Endurance

Mar 13 2024 13 mins  
In this episode, we discuss polarized training, which includes high-volume low intensity training and high-intensity training. We review the scientific literature pertaining to endurance performance, mechanisms of recovery debt, adaptations to various exercise modalities, and developing training programs around polarized training. MAF-180: https://philmaffetone.com/180-formula/ #ul

Muscle Loss & "Ozempic" - Prevention & What We Know | Nick Sterling, MD, PhD #8 | Nick Sterling, MD, PhD #8

Nov 21 2023 8 mins  
Does muscle loss occur in people taking GLP-1 receptor agonists such as semaglutide (marketed as "Ozempic" and "Wegovy") or combined GLP-1/GIP agonists like tirzepatide (marketed as "Mounjaro")? In this episode, we discuss current evidence regarding these next-generation weight loss drugs and muscle wasting, as well as principles of preventing muscle l

How “Ozempic” Works – Weight Loss, Weight Regain, & Neuroscience | Nick Sterling, MD, PhD #7

Jul 29 2023 11 mins  
How do drugs like Ozempic (semaglutide) cause weight loss? In this episode, we discuss how these drugs (GLP-1 receptor agonists) target specific areas in the brain to suppress appetite and facilitate weight loss. We also discuss clinical trials data suggesting that these drugs and/or the weight loss that they facilitate may have cardioprotective effects. Lastly, we will also examin

How Fats & Carbs Drive Food Intake | Nick Sterling, MD, PhD #6

Jul 29 2023 5 mins  
Highly processed foods have been shown to lead to weight gain and are thought to drive intake through several mechanisms. Recent research suggests that the effect of combining fats and carbs on appetite might be more than the sum of their individual effects. Highly processed foods, accordingly, might simulate increased intake via the ratio of macronutrients. Link to episode on ne

How Ultra-Processed Foods Drive Weight Gain | Nick Sterling, MD, PhD #5

Mar 07 2023 8 mins  
Growing scientific evidence suggests that highly processed foods are associated with increased risk of disease. Until recently, scientists were unable to study directly the effects of highly processed foods on humans. In this episode, we review one of the first highly controlled scientific trials demonstrating that ultra-processed foods lead to weight gain.  Neuroscience of ap

How Overeating Rewires Our Brains – Neuroscience of Weight Gain & Loss | Nick Sterling, MD, PhD #4

Dec 27 2022 31 mins  
In this episode, we discuss how overeating can lead to inflammation and neuron dysfunction in specific parts of the brain that control appetite and energy regulation. We review the neuroscience of appetite regulation, energy expenditure, and body fat regulation. Topics include hypothalamic dysfunction of body fat regulation, leptin resistance, neuro-inflammation, and physical chang