The Synthesis of Wellness

Nov 01 2024 149 ep. 40 mins 3
The Synthesis of Wellness Podcast artwork

Your host and biohacker, Chloe Porter, has a background in engineering, innovation, and research. Her analytical background coupled with her journey in overcoming a brain tumor and defeating several chronic illnesses enables her to approach health and wellness in an innovative way, and now more than ever, she is ready to share her biohacking secrets and expose cutting-edge research. Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

  Health & Fitness
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149. The Gut Microbiome & Serotonin Synthesis | Impacts of Intestinal Dysbiosis on Serotonin Production, Impacts of Low Serotonin on Gut Motility, & More

Nov 01 2024 18 mins  
In this episode, we explore serotonin synthesis within enterochromaffin (EC) cells in the gut, detailing how tryptophan is converted into serotonin through enzymatic processes. We examine the role of gut microbiota-derived metabolites, such as short-chain fatty acids (SCFAs), in modulating the synthesis of serotonin including impacting tryptophan hydroxylase activity. We explore se

148. 1,25-Dihydroxycholecalciferol & The Brain | Forms of Vitamin D, Activation to 1,25-Dihydroxycholecalciferol, Mechanisms of Action / Neuroprotective Effects of Vitamin D, Cognitive Symptoms

Oct 25 2024 19 mins  
In this episode, we explore the role of Vitamin D in brain health, focusing on how its active form, calcitriol (1,25-dihydroxyvitamin D3), influences cognitive function and neuroprotection. We’ll discuss the synthesis of Vitamin D, its conversion into its active form, and its ability to cross the blood-brain barrier to exert effects on neurons and glial cells. Additionally, we wi

147. Mindfulness, Gratitude, Manifestation, Habit-Formation, & More with Ron & Carri, The Co-Founders of The Sparkle Revolution App

Oct 23 2024 46 mins  
We are honored to be joined by Carri Norton and Ron Butterworth, the Co-Founders of the Sparkle Revolution App. Carri is an accomplished professional in software application development, with experience across various industries such as educational software, solar monitoring, energy management, and HVAC digital solutions. Starting her career as a software developer, she progressed

146. Neuroinflammation | How Chronic Microglial Cell Activation Can Contribute to Neurodegeneration, Factors That Activate Microglial Cells

Oct 18 2024 17 mins  
In this episode, we dive into the role of microglial cells, the brain’s resident immune defenders, and how their chronic activation at the cellular level contributes to neurodegeneration. We'll explore the cellular mechanisms behind microglial activation, including the involvement of P2Y12 receptors and the release of pro-inflammatory cytokines like IL-1β and TNF-α. Additionall

145. The Role of Secretory IgA in Regulating the Gut Microbiome and Protecting the Intestinal Lining | sIgA Testing & Causes of Low Levels

Oct 11 2024 20 mins  
In this episode, we explore the critical role of Secretory IgA (sIgA) in maintaining intestinal health. We discuss how sIgA acts as a frontline immune defense, preventing pathogens from adhering to the gut epithelium and aiding in controlling microbial populations. Additionally, we dive into the implications of low and high sIgA levels - as indicated in a stool test, how sIgA level

144. The Roles of the Vagus Nerve and Enteric Nervous System in Digestion and Intestinal Motility | Links to Small Intestinal Bacterial Overgrowth (SIBO)

Oct 04 2024 18 mins  
In this episode, we explore the critical roles of the enteric nervous system (ENS) and the vagus nerve in digestion and gut motility. We also examine how autonomic nervous system dysfunction can contribute to conditions such as Small Intestinal Bacterial Overgrowth (SIBO). Topics: 1. Introduction to the Nervous System and Its Role in Digestion - Overview of the enteric nervous

143. Postural Orthostatic Tachycardia Syndrome (POTS), Supporting the Vagus Nerve, & Powerful Supplementation with Dr. Diana Driscoll

Oct 02 2024 59 mins  
We are honored to be joined by Dr. Diana Driscoll. An authority on the autonomic nervous system, Dr. Diana Driscoll, Optometrist, FAAO, is a world-renowned expert on POTS (Postural Orthostatic Tachycardia Syndrome), and other “invisible” illnesses. As an author, speaker, inventor, and devoted researcher with five patents to date, she continues to push forward with dramatic shif

142. Neuroinflammation & Gut-Derived Lipopolysaccharides | Addressing Intestinal Dysbiosis, Intestinal Hyperpermeability, & Cognitive Function | Supporting the Gut-Microbiota-Brain Axis

Sep 27 2024 21 mins  
In today's episode, we dive into the molecular mechanisms underlying neuroinflammation, with a particular focus on how gut-derived endotoxins, such as lipopolysaccharides (LPS), perturb the blood-brain barrier (BBB) and propagate neuroinflammatory cascades. In more detail, we’ll discuss how intestinal dysbiosis and increased intestinal permeability can allow endotoxins such a

141. The Role that Gut-Microbiome Metabolites, Including Tryptophan Metabolites & Butyrate, Play in Supporting the Gut-Immune Axis | Tools for Supporting Butyrate Levels

Sep 20 2024 23 mins  
In this episode, we dive into how short-chain fatty acids (SCFAs), particularly butyrate, and tryptophan metabolites support the gut-immune axis by promoting regulatory T cell differentiation, strengthening the intestinal barrier, and enhancing antimicrobial defenses through IL-22 signaling. We break down how butyrate can improve immune tolerance as well as epithelial integrity, ai

140. Gastrointestinal Mucus & Its Role in Combating Increased Intestinal Permeability | Highlighting Mucins & Secretory IgA, Along with Tools to Support Optimal Mucus Levels & Protect the Epithelium

Sep 13 2024 20 mins  
In this episode, we explore the crucial role of the protective mucus layer in maintaining intestinal lining integrity, highlighting how it shields the epithelial cells from harmful substances and supports overall digestive function. We dive into the components and functions of mucins, goblet cells, and secretory IgA, explaining their contributions to gut immunity and barrier integr