The Synthesis of Wellness

Dec 06 2024 154 ep. 39 mins 1
The Synthesis of Wellness Podcast artwork

Your host and biohacker, Chloe Porter, has a background in engineering, innovation, and research. Her analytical background coupled with her journey in overcoming a brain tumor and defeating several chronic illnesses enables her to approach health and wellness in an innovative way, and now more than ever, she is ready to share her biohacking secrets and expose cutting-edge research. Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

  Health & Fitness
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154. Dysautonomia, The Vagus Nerve, & The Microbiota-Gut-Brain Axis | The Role That the Vagus Nerve Plays in Intestinal Health, Conditions and Root Causes Associated with Poor Function

Dec 06 2024 16 mins  
In this episode, we explore the intricate role of the vagus nerve as a central regulator within the microbiota-gut-brain (MGB) axis, examining its neuroanatomical structure, signaling mechanisms, and interactions with microbial metabolites and immune pathways. We discuss how vagal afferent fibers relay sensory input from the gut to the brain, including signals mediated by short-cha

153. The Role of the Intestinal Microbiome in Modulating HPA Axis Activity | Intestinal Barrier Function, Cortisol, Testing, & More

Nov 29 2024 17 mins  
In this episode, we dive into the interplay between the hypothalamic-pituitary-adrenal (HPA) axis and the microbiota-gut-brain (MGB) axis, highlighting their bidirectional communication through endocrine, immune, and neural pathways. We’ll explore how gut-derived metabolites like short-chain fatty acids (SCFAs) and endotoxins like LPS influence HPA axis activity; conversely, we e

152. The Effects of Aging on Intestinal Permeability, Immune Function, and the Gut-Immune Axis | Supporting Resilience in Gut Health with Age

Nov 22 2024 18 mins  
In this episode, we examine the bidirectional relationship between intestinal health and immune aging, emphasizing how gut barrier dysfunction and microbial imbalances accelerate systemic inflammation and diminished immune function. Furthermore, we explore the effects of aging on intestinal barrier function, focusing on the decline in tight junction integrity, reduced mucus product

151. The Gut-Immune Axis & the Beneficial Role of Immunoglobulins in Supporting Intestinal Barrier Function | IgG, Secretory IgA, and More

Nov 15 2024 16 mins  
In today’s episode, we dive into the interplay between the gut and immune system, focusing specifically on the critical role of immunoglobulins in mucosal immunity. Immunoglobulins, specialized glycoproteins synthesized by B cells, serve as the frontline defenders within the gastrointestinal tract, where they neutralize pathogens and maintain immune homeostasis. We also explore t

150. The Role of Phospholipids in Cognitive Health | How Phospholipids Including Phosphatidylserine Support Neuronal Communication, Tools to Support Phospholipid Levels, Neurodegenerative Conditions

Nov 08 2024 16 mins  
In today’s episode, we dive into the critical role of phospholipids in maintaining brain health, examining how these molecules contribute to neuronal communication, synaptic plasticity, and cognitive resilience. We'll explore the biochemical structure and function of key phospholipids like phosphatidylserine and phosphatidylcholine within neuronal membranes, where they play indis

149. The Gut Microbiome & Serotonin Synthesis | Impacts of Intestinal Dysbiosis on Serotonin Production, Impacts of Low Serotonin on Gut Motility, & More

Nov 01 2024 18 mins  
In this episode, we explore serotonin synthesis within enterochromaffin (EC) cells in the gut, detailing how tryptophan is converted into serotonin through enzymatic processes. We examine the role of gut microbiota-derived metabolites, such as short-chain fatty acids (SCFAs), in modulating the synthesis of serotonin including impacting tryptophan hydroxylase activity. We explore se

148. 1,25-Dihydroxycholecalciferol & The Brain | Forms of Vitamin D, Activation to 1,25-Dihydroxycholecalciferol, Mechanisms of Action / Neuroprotective Effects of Vitamin D, Cognitive Symptoms

Oct 25 2024 19 mins  
In this episode, we explore the role of Vitamin D in brain health, focusing on how its active form, calcitriol (1,25-dihydroxyvitamin D3), influences cognitive function and neuroprotection. We’ll discuss the synthesis of Vitamin D, its conversion into its active form, and its ability to cross the blood-brain barrier to exert effects on neurons and glial cells. Additionally, we wi

147. Mindfulness, Gratitude, Manifestation, Habit-Formation, & More with Ron & Carri, The Co-Founders of The Sparkle Revolution App

Oct 23 2024 46 mins  
We are honored to be joined by Carri Norton and Ron Butterworth, the Co-Founders of the Sparkle Revolution App. Carri is an accomplished professional in software application development, with experience across various industries such as educational software, solar monitoring, energy management, and HVAC digital solutions. Starting her career as a software developer, she progressed

146. Neuroinflammation | How Chronic Microglial Cell Activation Can Contribute to Neurodegeneration, Factors That Activate Microglial Cells

Oct 18 2024 17 mins  
In this episode, we dive into the role of microglial cells, the brain’s resident immune defenders, and how their chronic activation at the cellular level contributes to neurodegeneration. We'll explore the cellular mechanisms behind microglial activation, including the involvement of P2Y12 receptors and the release of pro-inflammatory cytokines like IL-1β and TNF-α. Additionall

145. The Role of Secretory IgA in Regulating the Gut Microbiome and Protecting the Intestinal Lining | sIgA Testing & Causes of Low Levels

Oct 11 2024 20 mins  
In this episode, we explore the critical role of Secretory IgA (sIgA) in maintaining intestinal health. We discuss how sIgA acts as a frontline immune defense, preventing pathogens from adhering to the gut epithelium and aiding in controlling microbial populations. Additionally, we dive into the implications of low and high sIgA levels - as indicated in a stool test, how sIgA level